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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Bell CC, Hendriks DF, Moro SM, Ellis E, Walsh J, Renblom A, Fredriksson Puigvert L, Dankers AC, Jacobs F, Snoeys J, Sison-Young RL, Jenkins RE, Nordling Å, Mkrtchian S, Park BK, Kitteringham NR, Goldring CE, Lauschke VM, Ingelman-Sundberg M. Bell CC, et al. Among authors: walsh j. Sci Rep. 2016 May 4;6:25187. doi: 10.1038/srep25187. Sci Rep. 2016. PMID: 27143246 Free PMC article.
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.
Heslop JA, Rowe C, Walsh J, Sison-Young R, Jenkins R, Kamalian L, Kia R, Hay D, Jones RP, Malik HZ, Fenwick S, Chadwick AE, Mills J, Kitteringham NR, Goldring CE, Kevin Park B. Heslop JA, et al. Among authors: walsh j. Arch Toxicol. 2017 Jan;91(1):439-452. doi: 10.1007/s00204-016-1694-y. Epub 2016 Apr 2. Arch Toxicol. 2017. PMID: 27039104 Free PMC article.
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK. Kitteringham NR, et al. Among authors: walsh j. J Proteomics. 2010 Jun 16;73(8):1612-31. doi: 10.1016/j.jprot.2010.03.018. Epub 2010 Apr 24. J Proteomics. 2010. PMID: 20399915 Free PMC article.
Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
Yeang HXA, Hamdam JM, Al-Huseini LMA, Sethu S, Djouhri L, Walsh J, Kitteringham N, Park BK, Goldring CE, Sathish JG. Yeang HXA, et al. Among authors: walsh j. J Biol Chem. 2012 Mar 23;287(13):10556-10564. doi: 10.1074/jbc.M111.322420. Epub 2012 Feb 6. J Biol Chem. 2012. PMID: 22311972 Free PMC article.
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney.
Shelton LM, Lister A, Walsh J, Jenkins RE, Wong MH, Rowe C, Ricci E, Ressel L, Fang Y, Demougin P, Vukojevic V, O'Neill PM, Goldring CE, Kitteringham NR, Park BK, Odermatt A, Copple IM. Shelton LM, et al. Among authors: walsh j. Kidney Int. 2015 Dec;88(6):1261-1273. doi: 10.1038/ki.2015.286. Epub 2015 Sep 30. Kidney Int. 2015. PMID: 26422507 Free PMC article.
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.
Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K. Cai H, et al. Among authors: walsh j. Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619. Sci Transl Med. 2015. PMID: 26223300 Free PMC article.
5,872 results