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eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
Schmidt T, Dabrowska A, Waldron JA, Hodge K, Koulouras G, Gabrielsen M, Munro J, Tack DC, Harris G, McGhee E, Scott D, Carlin LM, Huang D, Le Quesne J, Zanivan S, Wilczynska A, Bushell M. Schmidt T, et al. Among authors: waldron ja. Nucleic Acids Res. 2023 Feb 28;51(4):1859-1879. doi: 10.1093/nar/gkad030. Nucleic Acids Res. 2023. PMID: 36727461 Free PMC article.
The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
Smith EM, Benbahouche NEH, Morris K, Wilczynska A, Gillen S, Schmidt T, Meijer HA, Jukes-Jones R, Cain K, Jones C, Stoneley M, Waldron JA, Bell C, Fonseca BD, Blagden S, Willis AE, Bushell M. Smith EM, et al. Among authors: waldron ja. Nucleic Acids Res. 2021 Jan 11;49(1):458-478. doi: 10.1093/nar/gkaa1189. Nucleic Acids Res. 2021. PMID: 33332560 Free PMC article.
Codon optimality in cancer.
Gillen SL, Waldron JA, Bushell M. Gillen SL, et al. Among authors: waldron ja. Oncogene. 2021 Nov;40(45):6309-6320. doi: 10.1038/s41388-021-02022-x. Epub 2021 Sep 28. Oncogene. 2021. PMID: 34584217 Free PMC article. Review.
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JD, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. Knight JRP, et al. Among authors: waldron ja. Cancer Discov. 2021 May;11(5):1228-1247. doi: 10.1158/2159-8290.CD-20-0652. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328217 Free PMC article.
Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.
Ghashghaei M, Liu Y, Ettles J, Bombaci G, Ramkumar N, Liu Z, Escano L, Miko SS, Kim Y, Waldron JA, Do K, MacPherson K, Yuen KA, Taibi T, Yue M, Arsalan A, Jin Z, Edin G, Karsan A, Morin GB, Kuchenbauer F, Perna F, Bushell M, Vu LP. Ghashghaei M, et al. Among authors: waldron ja. Nat Commun. 2024 Mar 15;15(1):2340. doi: 10.1038/s41467-024-46665-2. Nat Commun. 2024. PMID: 38491013 Free PMC article.
79 results