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Alzheimer's disease-associated mutant ubiquitin (UBB+1) is secreted through an autophagosome-like vesicle-mediated unconventional pathway.
Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194936. doi: 10.1016/j.bbagrm.2023.194936. Epub 2023 Apr 17.
Biochim Biophys Acta Gene Regul Mech. 2023.
PMID: 37075976
Review.
Ubiquitin-independent proteasomal degradation driven by C-degron pathways.
Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren I.
Makaros Y, et al. Among authors: wagh ar.
Mol Cell. 2023 Jun 1;83(11):1921-1935.e7. doi: 10.1016/j.molcel.2023.04.023. Epub 2023 May 17.
Mol Cell. 2023.
PMID: 37201526
Free PMC article.
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Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2.
Wagh AR, Bose K.
Wagh AR, et al.
Biosci Rep. 2018 Oct 5;38(5):BSR20181072. doi: 10.1042/BSR20181072. Print 2018 Oct 31.
Biosci Rep. 2018.
PMID: 30068699
Free PMC article.
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