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Page 1
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. Sachs N, et al. Among authors: vries rgj. Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7. Cell. 2018. PMID: 29224780 Free article.
Establishment of Pancreatic Organoids from Normal Tissue and Tumors.
Driehuis E, Gracanin A, Vries RGJ, Clevers H, Boj SF. Driehuis E, et al. Among authors: vries rgj. STAR Protoc. 2020 Dec 4;1(3):100192. doi: 10.1016/j.xpro.2020.100192. eCollection 2020 Dec 18. STAR Protoc. 2020. PMID: 33377086 Free PMC article.
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response.
Smabers LP, Wensink E, Verissimo CS, Koedoot E, Pitsa KC, Huismans MA, Higuera Barón C, Doorn M, Valkenburg-van Iersel LB, Cirkel GA, Brousali A, Overmeer R, Koopman M, Braat MN, Penning de Vries B, Elias SG, Vries RG, Kranenburg O, Boj SF, Roodhart JM. Smabers LP, et al. J Exp Clin Cancer Res. 2024 Feb 27;43(1):61. doi: 10.1186/s13046-024-02980-6. J Exp Clin Cancer Res. 2024. PMID: 38414064 Free PMC article.
Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.
Carr DF, Ayehunie S, Davies A, Duckworth CA, French S, Hall N, Hussain S, Mellor HR, Norris A, Park BK, Penrose A, Pritchard DM, Probert CS, Ramaiah S, Sadler C, Schmitt M, Shaw A, Sidaway JE, Vries RG, Wagoner M, Pirmohamed M. Carr DF, et al. Pharmacol Ther. 2017 Apr;172:181-194. doi: 10.1016/j.pharmthera.2017.01.002. Epub 2017 Jan 27. Pharmacol Ther. 2017. PMID: 28132905 Review.
Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.
Kourula S, Derksen M, Jardi F, Jonkers S, van Heerden M, Verboven P, Theuns V, Van Asten S, Huybrechts T, Kunze A, Frazer-Mendelewska E, Lai KW, Overmeer R, Roos JL, Vries RGJ, Boj SF, Monshouwer M, Pourfarzad F, Snoeys J. Kourula S, et al. Among authors: vries rgj. Eur J Pharm Sci. 2023 Sep 1;188:106481. doi: 10.1016/j.ejps.2023.106481. Epub 2023 May 25. Eur J Pharm Sci. 2023. PMID: 37244450 Free article.
A living biobank of matched pairs of patient-derived xenografts and organoids for cancer pharmacology.
Xu X, Kumari R, Zhou J, Chen J, Mao B, Wang J, Zheng M, Tu X, An X, Chen X, Zhang L, Tian X, Wang H, Dong X, Bao Z, Guo S, Ouyang X, Shang L, Wang F, Yan X, Zhang R, Vries RGJ, Clevers H, Li QX. Xu X, et al. Among authors: vries rgj. PLoS One. 2023 Jan 5;18(1):e0279821. doi: 10.1371/journal.pone.0279821. eCollection 2023. PLoS One. 2023. PMID: 36602988 Free PMC article.
Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier.
Jelinsky SA, Derksen M, Bauman E, Verissimo CS, van Dooremalen WTM, Roos JL, Higuera Barón C, Caballero-Franco C, Johnson BG, Rooks MG, Pott J, Oldenburg B, Vries RGJ, Boj SF, Kasaian MT, Pourfarzad F, Rosadini CV. Jelinsky SA, et al. Among authors: vries rgj. Inflamm Bowel Dis. 2023 Feb 1;29(2):195-206. doi: 10.1093/ibd/izac212. Inflamm Bowel Dis. 2023. PMID: 36356046 Free PMC article.
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.
Herpers B, Eppink B, James MI, Cortina C, Cañellas-Socias A, Boj SF, Hernando-Momblona X, Glodzik D, Roovers RC, van de Wetering M, Bartelink-Clements C, Zondag-van der Zande V, Mateos JG, Yan K, Salinaro L, Basmeleh A, Fatrai S, Maussang D, Lammerts van Bueren JJ, Chicote I, Serna G, Cabellos L, Ramírez L, Nuciforo P, Salazar R, Santos C, Villanueva A, Stephan-Otto Attolini C, Sancho E, Palmer HG, Tabernero J, Stratton MR, de Kruif J, Logtenberg T, Clevers H, Price LS, Vries RGJ, Batlle E, Throsby M. Herpers B, et al. Among authors: vries rgj. Nat Cancer. 2022 Apr;3(4):418-436. doi: 10.1038/s43018-022-00359-0. Epub 2022 Apr 25. Nat Cancer. 2022. PMID: 35469014 Free article.
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.
Ponsioen B, Post JB, Buissant des Amorie JR, Laskaris D, van Ineveld RL, Kersten S, Bertotti A, Sassi F, Sipieter F, Cappe B, Mertens S, Verlaan-Klink I, Boj SF, Vries RGJ, Rehmann H, Vandenabeele P, Riquet FB, Trusolino L, Bos JL, Snippert HJG. Ponsioen B, et al. Among authors: vries rgj. Nat Cell Biol. 2021 Apr;23(4):377-390. doi: 10.1038/s41556-021-00654-5. Epub 2021 Apr 1. Nat Cell Biol. 2021. PMID: 33795873 Free PMC article.
33 results