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Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T. Brown RJP, et al. Among authors: vondran fwr. Sci Adv. 2020 Nov 4;6(45):eabd3233. doi: 10.1126/sciadv.abd3233. Print 2020 Nov. Sci Adv. 2020. PMID: 33148654 Free PMC article.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E. Anggakusuma, et al. Hepatology. 2015 Sep;62(3):702-14. doi: 10.1002/hep.27913. Epub 2015 Jul 28. Hepatology. 2015. PMID: 25999047
Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T. Perin PM, et al. Hepatology. 2016 Jan;63(1):49-62. doi: 10.1002/hep.28111. Epub 2015 Oct 9. Hepatology. 2016. PMID: 26248546 Free PMC article.
Host cell mTORC1 is required for HCV RNA replication.
Stöhr S, Costa R, Sandmann L, Westhaus S, Pfaender S, Anggakusuma, Dazert E, Meuleman P, Vondran FW, Manns MP, Steinmann E, von Hahn T, Ciesek S. Stöhr S, et al. Gut. 2016 Dec;65(12):2017-2028. doi: 10.1136/gutjnl-2014-308971. Epub 2015 Aug 14. Gut. 2016. PMID: 26276683 Free PMC article.
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.
Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V. Harak C, et al. Nat Microbiol. 2016 Dec 19;2:16247. doi: 10.1038/nmicrobiol.2016.247. Nat Microbiol. 2016. PMID: 27991882
156 results