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Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.
Liu X, Pichulik T, Wolz OO, Dang TM, Stutz A, Dillen C, Delmiro Garcia M, Kraus H, Dickhöfer S, Daiber E, Münzenmayer L, Wahl S, Rieber N, Kümmerle-Deschner J, Yazdi A, Franz-Wachtel M, Macek B, Radsak M, Vogel S, Schulte B, Walz JS, Hartl D, Latz E, Stilgenbauer S, Grimbacher B, Miller L, Brunner C, Wolz C, Weber ANR. Liu X, et al. Among authors: vogel s. J Allergy Clin Immunol. 2017 Oct;140(4):1054-1067.e10. doi: 10.1016/j.jaci.2017.01.017. Epub 2017 Feb 16. J Allergy Clin Immunol. 2017. PMID: 28216434
The NLRP3 inflammasome and bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation.
Murthy P, Durco F, Miller-Ocuin JL, Takedai T, Shankar S, Liang X, Liu X, Cui X, Sachdev U, Rath D, Lotze MT, Zeh HJ 3rd, Gawaz M, Weber AN, Vogel S. Murthy P, et al. Among authors: vogel s. Biochem Biophys Res Commun. 2017 Jan 29;483(1):230-236. doi: 10.1016/j.bbrc.2016.12.161. Epub 2016 Dec 26. Biochem Biophys Res Commun. 2017. PMID: 28034752
Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation.
Münzer P, Schmid E, Walker B, Fotinos A, Chatterjee M, Rath D, Vogel S, Hoffmann SM, Metzger K, Seizer P, Geisler T, Gawaz M, Borst O, Lang F. Münzer P, et al. Among authors: vogel s. Am J Physiol Cell Physiol. 2014 Nov 15;307(10):C920-7. doi: 10.1152/ajpcell.00029.2014. Epub 2014 Sep 17. Am J Physiol Cell Physiol. 2014. PMID: 25231106 Free PMC article.
1,435 results