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Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases.
Pérez-Jiménez MM, Monje-Moreno JM, Brokate-Llanos AM, Venegas-Calerón M, Sánchez-García A, Sansigre P, Valladares A, Esteban-García S, Suárez-Pereira I, Vitorica J, Ríos JJ, Artal-Sanz M, Carrión ÁM, Muñoz MJ. Pérez-Jiménez MM, et al. Among authors: vitorica j. Nat Commun. 2021 Jan 4;12(1):49. doi: 10.1038/s41467-020-20269-y. Nat Commun. 2021. PMID: 33397961 Free PMC article.
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels.
Alvarez-Vergara MI, Rosales-Nieves AE, March-Diaz R, Rodriguez-Perinan G, Lara-Ureña N, Ortega-de San Luis C, Sanchez-Garcia MA, Martin-Bornez M, Gómez-Gálvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena MA, Bullones-Bolanos AS, Davila JC, Gonzalez-Martinez R, Trillo-Contreras JL, Sanchez-Hidalgo AC, Del Toro R, Scholl FG, Herrera E, Trepel M, Körbelin J, Escudero LM, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A. Alvarez-Vergara MI, et al. Among authors: vitorica j. Nat Commun. 2021 May 25;12(1):3098. doi: 10.1038/s41467-021-23337-z. Nat Commun. 2021. PMID: 34035282 Free PMC article.
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer's disease hippocampus.
Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Gutierrez A, Vitorica J. Muñoz-Castro C, et al. Among authors: vitorica j. Acta Neuropathol Commun. 2023 Feb 28;11(1):31. doi: 10.1186/s40478-023-01530-z. Acta Neuropathol Commun. 2023. PMID: 36855152 Free PMC article.
Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1.
March-Diaz R, Lara-Ureña N, Romero-Molina C, Heras-Garvin A, Ortega-de San Luis C, Alvarez-Vergara MI, Sanchez-Garcia MA, Sanchez-Mejias E, Davila JC, Rosales-Nieves AE, Forja C, Navarro V, Gomez-Arboledas A, Sanchez-Mico MV, Viehweger A, Gerpe A, Hodson EJ, Vizuete M, Bishop T, Serrano-Pozo A, Lopez-Barneo J, Berra E, Gutierrez A, Vitorica J, Pascual A. March-Diaz R, et al. Among authors: vitorica j. Nat Aging. 2021 Apr;1(4):385-399. doi: 10.1038/s43587-021-00054-2. Epub 2021 Apr 15. Nat Aging. 2021. PMID: 37117599
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Trujillo-Estrada L, et al. Among authors: vitorica j. Acta Neuropathol Commun. 2013 Nov 12;1:73. doi: 10.1186/2051-5960-1-73. Acta Neuropathol Commun. 2013. PMID: 24252759 Free PMC article.
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.
Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A. Sanchez-Mejias E, et al. Among authors: vitorica j. Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. Brain Pathol. 2020. PMID: 31491047 Free PMC article.
Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.
Fernandez-Valenzuela JJ, Sanchez-Varo R, Muñoz-Castro C, De Castro V, Sanchez-Mejias E, Navarro V, Jimenez S, Nuñez-Diaz C, Gomez-Arboledas A, Moreno-Gonzalez I, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Fernandez-Valenzuela JJ, et al. Among authors: vitorica j. Sci Rep. 2020 Sep 8;10(1):14776. doi: 10.1038/s41598-020-71767-4. Sci Rep. 2020. PMID: 32901091 Free PMC article.
113 results