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Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.
Archambault AS, Tinto F, Dumais É, Rakotoarivelo V, Kostrzewa M, Plante PL, Martin C, Simard M, Silvestri C, Pouliot R, Laviolette M, Boulet LP, Vitale RM, Ligresti A, Di Marzo V, Flamand N. Archambault AS, et al. Among authors: vitale rm. Cells. 2021 Sep 5;10(9):2322. doi: 10.3390/cells10092322. Cells. 2021. PMID: 34571971 Free PMC article.
Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists.
Schiano Moriello A, López Chinarro S, Novo Fernández O, Eras J, Amodeo P, Canela-Garayoa R, Vitale RM, Di Marzo V, De Petrocellis L. Schiano Moriello A, et al. Among authors: vitale rm. J Med Chem. 2018 Sep 27;61(18):8255-8281. doi: 10.1021/acs.jmedchem.8b00734. Epub 2018 Sep 14. J Med Chem. 2018. PMID: 30176215
FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.
Ligresti A, Silvestri C, Vitale RM, Martos JL, Piscitelli F, Wang JW, Allarà M, Carling RW, Luongo L, Guida F, Illiano A, Amoresano A, Maione S, Amodeo P, Woodward DF, Di Marzo V, Marino G. Ligresti A, et al. Among authors: vitale rm. ACS Chem Neurosci. 2019 Jan 16;10(1):424-437. doi: 10.1021/acschemneuro.8b00315. Epub 2018 Oct 4. ACS Chem Neurosci. 2019. PMID: 30226747
Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.
Vitale RM, D'Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani ME, Fellous T, Gentile A, Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D'Aniello B, Defranoux F, Felline S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E. Vitale RM, et al. Mar Drugs. 2018 Nov 3;16(11):431. doi: 10.3390/md16110431. Mar Drugs. 2018. PMID: 30400299 Free PMC article.
Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.
D'Aniello E, Fellous T, Iannotti FA, Gentile A, Allarà M, Balestrieri F, Gray R, Amodeo P, Vitale RM, Di Marzo V. D'Aniello E, et al. Among authors: vitale rm. Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):586-597. doi: 10.1016/j.bbagen.2019.01.002. Epub 2019 Jan 3. Biochim Biophys Acta Gen Subj. 2019. PMID: 30611848
In Silico Identification and Experimental Validation of (-)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator.
D'Aniello E, Iannotti FA, Falkenberg LG, Martella A, Gentile A, De Maio F, Ciavatta ML, Gavagnin M, Waxman JS, Di Marzo V, Amodeo P, Vitale RM. D'Aniello E, et al. Among authors: vitale rm. Mar Drugs. 2019 Feb 12;17(2):110. doi: 10.3390/md17020110. Mar Drugs. 2019. PMID: 30759808 Free PMC article.
Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.
Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, Everard A, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Delzenne NM, de Vos WM, Di Marzo V, Cani PD. Depommier C, et al. Among authors: vitale rm. Cells. 2021 Jan 19;10(1):185. doi: 10.3390/cells10010185. Cells. 2021. PMID: 33477821 Free PMC article. Clinical Trial.
66 results