Virshup DM - Search Results

1

Structural model of human PORCN illuminates disease-associated variants and drug-binding sites.

Yu J, Liao PJ, Xu W, Jones JR, Everman DB, Flanagan-Steet H, Keller TH, Virshup DM. Yu J, et al. Among authors: virshup dm. J Cell Sci. 2021 Dec 15;134(24):jcs259383. doi: 10.1242/jcs.259383. Epub 2021 Dec 20. J Cell Sci. 2021. PMID: 34817055

2

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.

Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, Ireland CM, Virshup DM. Coombs GS, et al. Among authors: virshup dm. J Cell Sci. 2010 Oct 1;123(Pt 19):3357-67. doi: 10.1242/jcs.072132. Epub 2010 Sep 7. J Cell Sci. 2010. PMID: 20826466 Free PMC article.

3

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.

Covey TM, Kaur S, Tan Ong T, Proffitt KD, Wu Y, Tan P, Virshup DM. Covey TM, et al. Among authors: virshup dm. PLoS One. 2012;7(4):e34532. doi: 10.1371/journal.pone.0034532. Epub 2012 Apr 11. PLoS One. 2012. PMID: 22509316 Free PMC article.

4

Precise regulation of porcupine activity is required for physiological Wnt signaling.

Proffitt KD, Virshup DM. Proffitt KD, et al. Among authors: virshup dm. J Biol Chem. 2012 Oct 5;287(41):34167-78. doi: 10.1074/jbc.M112.381970. Epub 2012 Aug 10. J Biol Chem. 2012. PMID: 22888000 Free PMC article.

5

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, Hannoush RN, Virshup DM. Proffitt KD, et al. Among authors: virshup dm. Cancer Res. 2013 Jan 15;73(2):502-7. doi: 10.1158/0008-5472.CAN-12-2258. Epub 2012 Nov 27. Cancer Res. 2013. PMID: 23188502

6

WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.

Yu J, Chia J, Canning CA, Jones CM, Bard FA, Virshup DM. Yu J, et al. Among authors: virshup dm. Dev Cell. 2014 May 12;29(3):277-91. doi: 10.1016/j.devcel.2014.03.016. Epub 2014 Apr 24. Dev Cell. 2014. PMID: 24768165 Free article.

7

Updating the Wnt pathways.

Yu J, Virshup DM. Yu J, et al. Among authors: virshup dm. Biosci Rep. 2014 Oct 17;34(5):e00142. doi: 10.1042/BSR20140119. Biosci Rep. 2014. PMID: 25208913 Free PMC article.

8

Discovery and Optimization of a Porcupine Inhibitor.

Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, Virshup DM, Keller TH. Duraiswamy AJ, et al. Among authors: virshup dm. J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26110200

9

Wnt addiction of genetically defined cancers reversed by PORCN inhibition.

Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, Keller TH, Lee MA, Matter A, Virshup DM. Madan B, et al. Among authors: virshup dm, virshup ih. Oncogene. 2016 Apr 28;35(17):2197-207. doi: 10.1038/onc.2015.280. Epub 2015 Aug 10. Oncogene. 2016. PMID: 26257057 Free PMC article.

10

Wnt proteins synergize to activate β-catenin signaling.

Alok A, Lei Z, Jagannathan NS, Kaur S, Harmston N, Rozen SG, Tucker-Kellogg L, Virshup DM. Alok A, et al. Among authors: virshup dm. J Cell Sci. 2017 May 1;130(9):1532-1544. doi: 10.1242/jcs.198093. Epub 2017 Mar 13. J Cell Sci. 2017. PMID: 28289266

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