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The positive inside rule is stronger when followed by a transmembrane helix.
J Mol Biol. 2014 Aug 12;426(16):2982-91. doi: 10.1016/j.jmb.2014.06.002. Epub 2014 Jun 10.
J Mol Biol. 2014.
PMID: 24927974
Large tilts in transmembrane helices can be induced during tertiary structure formation.
Virkki M, Boekel C, Illergård K, Peters C, Shu N, Tsirigos KD, Elofsson A, von Heijne G, Nilsson I.
Virkki M, et al.
J Mol Biol. 2014 Jun 26;426(13):2529-38. doi: 10.1016/j.jmb.2014.04.020. Epub 2014 Apr 30.
J Mol Biol. 2014.
PMID: 24793448
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Folding of Aquaporin 1: multiple evidence that helix 3 can shift out of the membrane core.
Virkki MT, Agrawal N, Edsbäcker E, Cristobal S, Elofsson A, Kauko A.
Virkki MT, et al.
Protein Sci. 2014 Jul;23(7):981-92. doi: 10.1002/pro.2483. Epub 2014 May 14.
Protein Sci. 2014.
PMID: 24777974
Free PMC article.
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Manipulating the genetic code for membrane protein production: what have we learnt so far?
Nørholm MH, Light S, Virkki MT, Elofsson A, von Heijne G, Daley DO.
Nørholm MH, et al. Among authors: virkki mt.
Biochim Biophys Acta. 2012 Apr;1818(4):1091-6. doi: 10.1016/j.bbamem.2011.08.018. Epub 2011 Aug 22.
Biochim Biophys Acta. 2012.
PMID: 21884679
Free PMC article.
Review.
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Improved production of membrane proteins in Escherichia coli by selective codon substitutions.
Nørholm MH, Toddo S, Virkki MT, Light S, von Heijne G, Daley DO.
Nørholm MH, et al. Among authors: virkki mt.
FEBS Lett. 2013 Aug 2;587(15):2352-8. doi: 10.1016/j.febslet.2013.05.063. Epub 2013 Jun 12.
FEBS Lett. 2013.
PMID: 23769986
Free article.
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