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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, Backlund M, Simoff I, Leber AT, Berruga-Fernández T, Antonov D, Konda VR, Lindström S, Olanders G, Brandt P, Baranczewski P, Vingsbo Lundberg C, Liepinsh E, Suna E, Jones TA, Mowbray SL, Hughes D, Karlén A. Huseby DL, et al. Among authors: vingsbo lundberg c. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121. doi: 10.1073/pnas.2317274121. Epub 2024 Apr 5. Proc Natl Acad Sci U S A. 2024. PMID: 38579010 Free PMC article.
Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages.
Ba X, Raisen CL, Restif O, Cavaco LM, Vingsbo Lundberg C, Lee JYH, Howden BP, Bartels MD, Strommenger B, Harrison EM, Larsen AR, Holmes MA, Larsen J. Ba X, et al. Among authors: vingsbo lundberg c. Nat Commun. 2023 Oct 14;14(1):6479. doi: 10.1038/s41467-023-42245-y. Nat Commun. 2023. PMID: 37838722 Free PMC article.
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
Aranzana-Climent V, Hughes D, Cao S, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hansen J, Lindberg J, Hobbie SN, Friberg LE. Aranzana-Climent V, et al. Among authors: vingsbo lundberg c. Clin Microbiol Infect. 2022 Oct;28(10):1367-1374. doi: 10.1016/j.cmi.2022.05.003. Epub 2022 May 20. Clin Microbiol Infect. 2022. PMID: 35598857 Free article.
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernández T, Huseby DL, Shariatgorji R, Lindmark E, Platzack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN. Becker K, et al. Among authors: vingsbo lundberg c. EBioMedicine. 2021 Nov;73:103652. doi: 10.1016/j.ebiom.2021.103652. Epub 2021 Nov 2. EBioMedicine. 2021. PMID: 34740109 Free PMC article.
ENABLE: an engine for European antibacterial drug discovery and development.
Olliver M, Griestop L, Hughes D, Belfrage AK, Gising J, Baranczewski P, Vingsbo Lundberg C, Karlén A. Olliver M, et al. Among authors: vingsbo lundberg c. Nat Rev Drug Discov. 2021 Jun;20(6):407-408. doi: 10.1038/d41573-021-00074-y. Nat Rev Drug Discov. 2021. PMID: 33948003 No abstract available.
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Sou T, Hansen J, Liepinsh E, Backlund M, Ercan O, Grinberga S, Cao S, Giachou P, Petersson A, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hughes D, Hobbie SN, Friberg LE. Sou T, et al. Among authors: vingsbo lundberg c. Clin Pharmacol Ther. 2021 Apr;109(4):1063-1073. doi: 10.1002/cpt.2104. Epub 2020 Nov 28. Clin Pharmacol Ther. 2021. PMID: 33150591 Free PMC article.
Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.
Harrison EM, Ba X, Coll F, Blane B, Restif O, Carvell H, Köser CU, Jamrozy D, Reuter S, Lovering A, Gleadall N, Bellis KL, Uhlemann AC, Lowy FD, Massey RC, Grilo IR, Sobral R, Larsen J, Rhod Larsen A, Vingsbo Lundberg C, Parkhill J, Paterson GK, Holden MTG, Peacock SJ, Holmes MA. Harrison EM, et al. Among authors: vingsbo lundberg c. Nat Microbiol. 2019 Oct;4(10):1680-1691. doi: 10.1038/s41564-019-0471-0. Epub 2019 Jun 24. Nat Microbiol. 2019. PMID: 31235959 Free PMC article.
In Vitro and In Vivo Characterization of NOSO-502, a Novel Inhibitor of Bacterial Translation.
Racine E, Nordmann P, Pantel L, Sarciaux M, Serri M, Houard J, Villain-Guillot P, Demords A, Vingsbo Lundberg C, Gualtieri M. Racine E, et al. Among authors: vingsbo lundberg c. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e01016-18. doi: 10.1128/AAC.01016-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29987155 Free PMC article.
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Pantel L, Florin T, Dobosz-Bartoszek M, Racine E, Sarciaux M, Serri M, Houard J, Campagne JM, de Figueiredo RM, Midrier C, Gaudriault S, Givaudan A, Lanois A, Forst S, Aumelas A, Cotteaux-Lautard C, Bolla JM, Vingsbo Lundberg C, Huseby DL, Hughes D, Villain-Guillot P, Mankin AS, Polikanov YS, Gualtieri M. Pantel L, et al. Among authors: vingsbo lundberg c. Mol Cell. 2018 Apr 5;70(1):83-94.e7. doi: 10.1016/j.molcel.2018.03.001. Mol Cell. 2018. PMID: 29625040 Free article.
23 results