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Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling.
Deroche L, Aranzana-Climent V, Rozenholc A, Prouvensier L, Darnaud L, Grégoire N, Marchand S, Ploy M-C, François B, Couet W, Barraud O, Buyck JM. Deroche L, et al. Among authors: aranzana climent v. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0048023. doi: 10.1128/aac.00480-23. Epub 2023 Sep 11. Antimicrob Agents Chemother. 2023. PMID: 37695298 Free PMC article.
Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents.
Arrazuria R, Kerscher B, Huber KE, Hoover JL, Lundberg CV, Hansen JU, Sordello S, Renard S, Aranzana-Climent V, Hughes D, Gribbon P, Friberg LE, Bekeredjian-Ding I. Arrazuria R, et al. Among authors: aranzana climent v. Front Microbiol. 2022 Sep 8;13:988728. doi: 10.3389/fmicb.2022.988728. eCollection 2022. Front Microbiol. 2022. PMID: 36160241 Free PMC article. Review.
Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections.
Arrazuria R, Kerscher B, Huber KE, Hoover JL, Lundberg CV, Hansen JU, Sordello S, Renard S, Aranzana-Climent V, Hughes D, Gribbon P, Friberg LE, Bekeredjian-Ding I. Arrazuria R, et al. Among authors: aranzana climent v. Front Microbiol. 2022 Sep 8;13:988725. doi: 10.3389/fmicb.2022.988725. eCollection 2022. Front Microbiol. 2022. PMID: 36160186 Free PMC article.
Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia.
Aranzana-Climent V, Hughes D, Cao S, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hansen J, Lindberg J, Hobbie SN, Friberg LE. Aranzana-Climent V, et al. Clin Microbiol Infect. 2022 Oct;28(10):1367-1374. doi: 10.1016/j.cmi.2022.05.003. Epub 2022 May 20. Clin Microbiol Infect. 2022. PMID: 35598857 Free article.
A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro.
Akrong G, Chauzy A, Aranzana-Climent V, Lacroix M, Deroche L, Prouvensier L, Buyck JM, Couet W, Marchand S. Akrong G, et al. Among authors: aranzana climent v. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0178921. doi: 10.1128/AAC.01789-21. Epub 2021 Nov 15. Antimicrob Agents Chemother. 2022. PMID: 34780268 Free PMC article.
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Becker K, Aranzana-Climent V, Cao S, Nilsson A, Shariatgorji R, Haldimann K, Platzack B, Hughes D, Andrén PE, Böttger EC, Friberg LE, Hobbie SN; ENABLE consortium. Becker K, et al. Among authors: aranzana climent v. Clin Microbiol Infect. 2021 Sep;27(9):1315-1321. doi: 10.1016/j.cmi.2020.12.004. Epub 2020 Dec 11. Clin Microbiol Infect. 2021. PMID: 33316399 Free article.
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