Villetti G - Search Results

1

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β₂ Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.

Carzaniga L, Linney ID, Rizzi A, Delcanale M, Schmidt W, Knight CK, Pastore F, Miglietta D, Carnini C, Cesari N, Riccardi B, Mileo V, Venturi L, Moretti E, Blackaby WP, Patacchini R, Accetta A, Biagetti M, Bassani F, Tondelli M, Murgo A, Battipaglia L, Villetti G, Puccini P, Catinella S, Civelli M, Rancati F. Carzaniga L, et al. Among authors: villetti g. J Med Chem. 2022 Aug 11;65(15):10233-10250. doi: 10.1021/acs.jmedchem.2c00609. Epub 2022 Jul 28. J Med Chem. 2022. PMID: 35901125

2

Preclinical evaluation of CHF3381 as a novel antiepileptic agent.

Villetti G, Bregola G, Bassani F, Bergamaschi M, Rondelli I, Pietra C, Simonato M. Villetti G, et al. Neuropharmacology. 2001 Jun;40(7):866-78. doi: 10.1016/s0028-3908(01)00026-0. Neuropharmacology. 2001. PMID: 11378157

3

Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.

Villetti G, Bergamaschi M, Bassani F, Bolzoni PT, Maiorino M, Pietra C, Rondelli I, Chamiot-Clerc P, Simonato M, Barbieri M. Villetti G, et al. J Pharmacol Exp Ther. 2003 Aug;306(2):804-14. doi: 10.1124/jpet.103.050039. Epub 2003 May 15. J Pharmacol Exp Ther. 2003. PMID: 12750440

4

High throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescence.

Albrecht H, Zbinden P, Rizzi A, Villetti G, Riccardi B, Puccini P, Catinella S, Imbimbo BP. Albrecht H, et al. Among authors: villetti g. Comb Chem High Throughput Screen. 2004 Dec;7(8):745-56. doi: 10.2174/1386207043328256. Comb Chem High Throughput Screen. 2004. PMID: 15578936

5

CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.

Bassani F, Bergamaschi M, Tonino Bolzoni P, Villetti G. Bassani F, et al. Among authors: villetti g. Eur J Pharmacol. 2005 Sep 20;519(3):231-6. doi: 10.1016/j.ejphar.2005.07.004. Eur J Pharmacol. 2005. PMID: 16125167

6

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

Peretto I, Radaelli S, Parini C, Zandi M, Raveglia LF, Dondio G, Fontanella L, Misiano P, Bigogno C, Rizzi A, Riccardi B, Biscaioli M, Marchetti S, Puccini P, Catinella S, Rondelli I, Cenacchi V, Bolzoni PT, Caruso P, Villetti G, Facchinetti F, Del Giudice E, Moretto N, Imbimbo BP. Peretto I, et al. Among authors: villetti g. J Med Chem. 2005 Sep 8;48(18):5705-20. doi: 10.1021/jm0502541. J Med Chem. 2005. PMID: 16134939

7

Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives.

Ghidini E, Delcanale M, De Fanti R, Rizzi A, Mazzuferi M, Rodi D, Simonato M, Lipreri M, Bassani F, Battipaglia L, Bergamaschi M, Villetti G. Ghidini E, et al. Among authors: villetti g. Bioorg Med Chem. 2006 May 15;14(10):3263-74. doi: 10.1016/j.bmc.2005.12.064. Epub 2006 Feb 3. Bioorg Med Chem. 2006. PMID: 16460950

8

Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium and ipratropium in guinea-pig and human airways.

Villetti G, Bergamaschi M, Bassani F, Bolzoni PT, Harrison S, Gigli PM, Janni A, Geppetti P, Civelli M, Patacchini R. Villetti G, et al. Br J Pharmacol. 2006 Jun;148(3):291-8. doi: 10.1038/sj.bjp.0706724. Br J Pharmacol. 2006. PMID: 16565730 Free PMC article.

9

Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).

Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D. Bartolucci C, et al. Among authors: villetti g. J Med Chem. 2006 Aug 24;49(17):5051-8. doi: 10.1021/jm060293s. J Med Chem. 2006. PMID: 16913695

10

In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.

Imbimbo BP, Del Giudice E, Cenacchi V, Volta R, Villetti G, Facchinetti F, Riccardi B, Puccini P, Moretto N, Grassi F, Ottonello S, Leon A. Imbimbo BP, et al. Among authors: villetti g. Pharmacol Res. 2007 Apr;55(4):318-28. doi: 10.1016/j.phrs.2006.12.010. Epub 2007 Jan 16. Pharmacol Res. 2007. PMID: 17292621

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