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Anti-tubercular profile of new selenium-menadione conjugates against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain and multidrug-resistant clinical isolates.
Ribeiro RCB, de Marins DB, Di Leo I, da Silva Gomes L, de Moraes MG, Abbadi BL, Villela AD, da Silva WF, da Silva LCRP, Machado P, Bizarro CV, Basso LA, Cristina de Moraes M, Ferreira VF, da Silva FC, Nascimento V. Ribeiro RCB, et al. Among authors: villela ad. Eur J Med Chem. 2021 Jan 1;209:112859. doi: 10.1016/j.ejmech.2020.112859. Epub 2020 Sep 23. Eur J Med Chem. 2021. PMID: 33010635 Free PMC article.
New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.
Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS. Giacobbo BC, et al. Among authors: villela ad. Eur J Med Chem. 2017 Jan 27;126:491-501. doi: 10.1016/j.ejmech.2016.11.048. Epub 2016 Nov 23. Eur J Med Chem. 2017. PMID: 27914363
Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing.
Subtil FT, Villela AD, Abbadi BL, Rodrigues-Junior VS, Bizarro CV, Timmers LFSM, de Souza ON, Pissinate K, Machado P, López-Gavín A, Tudó G, González-Martín J, Basso LA, Santos DS. Subtil FT, et al. Among authors: villela ad. Int J Antimicrob Agents. 2018 Mar;51(3):378-384. doi: 10.1016/j.ijantimicag.2017.08.023. Epub 2017 Aug 23. Int J Antimicrob Agents. 2018. PMID: 28843821 Free article.
1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity.
Macchi FS, Pissinate K, Villela AD, Abbadi BL, Rodrigues-Junior V, Nabinger DD, Altenhofen S, Sperotto N, da Silva Dadda A, Subtil FT, de Freitas TF, Erhart Rauber AP, Borsoi AF, Bonan CD, Bizarro CV, Basso LA, Santos DS, Machado P. Macchi FS, et al. Among authors: villela ad. Eur J Med Chem. 2018 Jul 15;155:153-164. doi: 10.1016/j.ejmech.2018.06.005. Epub 2018 Jun 2. Eur J Med Chem. 2018. PMID: 29885576
Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection.
Rodrigues-Junior VS, Villela AD, Gonçalves RS, Abbadi BL, Trindade RV, López-Gavín A, Tudó G, González-Martín J, Basso LA, de Souza MV, Campos MM, Santos DS. Rodrigues-Junior VS, et al. Among authors: villela ad. Int J Antimicrob Agents. 2016 Aug;48(2):203-7. doi: 10.1016/j.ijantimicag.2016.04.029. Epub 2016 Jun 7. Int J Antimicrob Agents. 2016. PMID: 27364701
Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme.
Martinelli LKB, Rotta M, Villela AD, Rodrigues-Junior VS, Abbadi BL, Trindade RV, Petersen GO, Danesi GM, Nery LR, Pauli I, Campos MM, Bonan CD, de Souza ON, Basso LA, Santos DS. Martinelli LKB, et al. Among authors: villela ad. Sci Rep. 2017 Apr 24;7:46696. doi: 10.1038/srep46696. Sci Rep. 2017. PMID: 28436453 Free PMC article.
26 results