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Sofosbuvir shows a protective effect against vertical transmission of Zika virus and the associated congenital syndrome in rhesus monkeys.
Gardinali NR, Marchevsky RS, Oliveira JM, Pelajo-Machado M, Kugelmeier T, Castro MP, Silva ACA, Pinto DP, Fonseca LB, Vilhena LS, Pereira HM, Lima SMB, Miranda EH, Trindade GF, Linhares JHR, Silva SA, Melgaço JG, Alves AMB, Moran J, Silva MCC, Soares-Bezerra RJ, Soriano A, Bentes GA, Bottino FO, Salvador Castro Faria SB, Nudelman RF, Lopes CAA, Perea JAS, Sarges K, Andrade MCR, Motta MCVA, Freire MS, Souza TML, Schmidt-Chanasit J, Pinto MA. Gardinali NR, et al. Among authors: vilhena ls. Antiviral Res. 2020 Oct;182:104859. doi: 10.1016/j.antiviral.2020.104859. Epub 2020 Jul 7. Antiviral Res. 2020. PMID: 32649965
Cynomolgus monkeys are successfully and persistently infected with hepatitis E virus genotype 3 (HEV-3) after long-term immunosuppressive therapy.
Gardinali NR, Guimarães JR, Melgaço JG, Kevorkian YB, Bottino FO, Vieira YR, da Silva AC, Pinto DP, da Fonseca LB, Vilhena LS, Uiechi E, da Silva MC, Moran J, Marchevsky RS, Cruz OG, Otonel RA, Alfieri AA, de Oliveira JM, Gaspar AM, Pinto MA. Gardinali NR, et al. Among authors: vilhena ls. PLoS One. 2017 Mar 22;12(3):e0174070. doi: 10.1371/journal.pone.0174070. eCollection 2017. PLoS One. 2017. PMID: 28328941 Free PMC article.
Development and validation of LC-MS/MS methods for the simultaneous quantification of sofosbuvir and its major metabolite (GS-331007) in blood plasma and cerebrospinal and seminal fluid: Application to a pilot clinical trial with a focus on Zika.
Vilhena LS, de Azevedo da Silva AC, Dias da Silva DM, Pinto DP, Coelho EF, de Araújo JFGM, da Silveira GPE, Pereira HM, da Silva LSFV, Estrela Marins RCE, Bortolini RG, Souza TML, Dos Santos VGV, de Assis Nascimento V, Amendoeira FC, da Fonseca LB. Vilhena LS, et al. Biomed Chromatogr. 2023 May;37(5):e5606. doi: 10.1002/bmc.5606. Epub 2023 Mar 5. Biomed Chromatogr. 2023. PMID: 36797051 Clinical Trial.