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Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance.
Naeem A, Utro F, Wang Q, Cha J, Vihinen M, Martindale S, Zhou Y, Ren Y, Tyekucheva S, Kim AS, Fernandes SM, Saksena G, Rhrissorrakrai K, Levovitz C, Danysh BP, Slowik K, Jacobs RA, Davids MS, Lederer JA, Zain R, Smith CIE, Leshchiner I, Parida L, Getz G, Brown JR. Naeem A, et al. Among authors: vihinen m. Blood Adv. 2023 May 9;7(9):1929-1943. doi: 10.1182/bloodadvances.2022008447. Blood Adv. 2023. PMID: 36287227 Free PMC article.
VariBench, new variation benchmark categories and data sets.
Shirvanizadeh N, Vihinen M. Shirvanizadeh N, et al. Among authors: vihinen m. Front Bioinform. 2023 Sep 19;3:1248732. doi: 10.3389/fbinf.2023.1248732. eCollection 2023. Front Bioinform. 2023. PMID: 37795169 Free PMC article. No abstract available.
Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions.
Johansson J, Lidéus S, Frykholm C, Gunnarsson C, Mihalic F, Gudmundsson S, Ekvall S, Molin AM, Pham M, Vihinen M, Lagerstedt-Robinson K, Nordgren A, Jemth P, Ameur A, Annerén G, Wilbe M, Bondeson ML. Johansson J, et al. Among authors: vihinen m. Eur J Hum Genet. 2024 Mar;32(3):333-341. doi: 10.1038/s41431-023-01392-y. Epub 2023 Jun 5. Eur J Hum Genet. 2024. PMID: 37277488 Free PMC article.
ProTstab2 for Prediction of Protein Thermal Stabilities.
Yang Y, Zhao J, Zeng L, Vihinen M. Yang Y, et al. Among authors: vihinen m. Int J Mol Sci. 2022 Sep 16;23(18):10798. doi: 10.3390/ijms231810798. Int J Mol Sci. 2022. PMID: 36142711 Free PMC article.
Individual Genetic Heterogeneity.
Vihinen M. Vihinen M. Genes (Basel). 2022 Sep 10;13(9):1626. doi: 10.3390/genes13091626. Genes (Basel). 2022. PMID: 36140794 Free PMC article. Review.
Generic model for biological regulation.
Vihinen M. Vihinen M. F1000Res. 2022 Apr 13;11:419. doi: 10.12688/f1000research.110944.2. eCollection 2022. F1000Res. 2022. PMID: 36128554 Free PMC article.
287 results