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A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites.
Beckham SA, Piedrafita D, Phillips CI, Samarawickrema N, Law RH, Smooker PM, Quinsey NS, Irving JA, Greenwood D, Verhelst SH, Bogyo M, Turk B, Coetzer TH, Wijeyewickrema LC, Spithill TW, Pike RN. Beckham SA, et al. Int J Biochem Cell Biol. 2009 Jul;41(7):1601-12. doi: 10.1016/j.biocel.2009.02.003. Epub 2009 Feb 20. Int J Biochem Cell Biol. 2009. PMID: 19401154 Free PMC article.
Probing functional tyrosines.
Verhelst SH. Verhelst SH. Chem Biol. 2013 Apr 18;20(4):457-8. doi: 10.1016/j.chembiol.2013.04.002. Chem Biol. 2013. PMID: 23601632
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