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Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.
Van den Bossche J, Lamers WH, Koehler ES, Geuns JM, Alhonen L, Uimari A, Pirnes-Karhu S, Van Overmeire E, Morias Y, Brys L, Vereecke L, De Baetselier P, Van Ginderachter JA. Van den Bossche J, et al. Among authors: vereecke l. J Leukoc Biol. 2012 May;91(5):685-99. doi: 10.1189/jlb.0911453. Epub 2012 Mar 13. J Leukoc Biol. 2012. PMID: 22416259
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.
Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P. Takahashi N, et al. Among authors: vereecke l. Nature. 2014 Sep 4;513(7516):95-9. doi: 10.1038/nature13706. Nature. 2014. PMID: 25186904
Microbes exploit death-induced nutrient release by gut epithelial cells.
Anderson CJ, Medina CB, Barron BJ, Karvelyte L, Aaes TL, Lambertz I, Perry JSA, Mehrotra P, Gonçalves A, Lemeire K, Blancke G, Andries V, Ghazavi F, Martens A, van Loo G, Vereecke L, Vandenabeele P, Ravichandran KS. Anderson CJ, et al. Among authors: vereecke l. Nature. 2021 Aug;596(7871):262-267. doi: 10.1038/s41586-021-03785-9. Epub 2021 Aug 4. Nature. 2021. PMID: 34349263
The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia.
De Spiegeleer A, Wynendaele E, Descamps A, Debunne N, Braeckman BP, De Mey M, Coudenys J, Crombez L, Verbeke F, Janssens Y, Janky R, Goossens E, Vlaeminck C, Duchi D, Andries V, Dumas E, Petrovic M, Van de Wiele T, Knappe D, Hoffmann R, Mouly V, Bigot A, Vereecke L, Van Immerseel F, Van Den Noortgate N, De Spiegeleer B, Elewaut D. De Spiegeleer A, et al. Among authors: vereecke l. Clin Transl Med. 2022 Oct;12(10):e1053. doi: 10.1002/ctm2.1053. Clin Transl Med. 2022. PMID: 36229976 Free PMC article. No abstract available.
Sterile triggers drive joint inflammation in TNF- and IL-1β-dependent mouse arthritis models.
Thiran A, Petta I, Blancke G, Thorp M, Planckaert G, Jans M, Andries V, Barbry K, Gilis E, Coudenys J, Hochepied T, Vanhove C, Gracey E, Dumas E, Manuelo T, Josipovic I, van Loo G, Elewaut D, Vereecke L. Thiran A, et al. Among authors: vereecke l. EMBO Mol Med. 2023 Oct 11;15(10):e17691. doi: 10.15252/emmm.202317691. Epub 2023 Sep 11. EMBO Mol Med. 2023. PMID: 37694693 Free PMC article.
The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice.
Eeckhout E, Asaoka T, Van Gorp H, Demon D, Girard-Guyonvarc'h C, Andries V, Vereecke L, Gabay C, Lamkanfi M, van Loo G, Wullaert A. Eeckhout E, et al. Among authors: vereecke l. Front Immunol. 2023 Nov 28;14:1272639. doi: 10.3389/fimmu.2023.1272639. eCollection 2023. Front Immunol. 2023. PMID: 38090573 Free PMC article.
Heart failure-induced microbial dysbiosis contributes to colonic tumour formation in mice.
de Wit S, Geerlings L, Shi C, Dronkers J, Schouten EM, Blancke G, Andries V, Yntema T, Meijers WC, Koonen DPY, Vereecke L, Silljé HHW, Aboumsallem JP, de Boer RA. de Wit S, et al. Among authors: vereecke l. Cardiovasc Res. 2024 May 7;120(6):612-622. doi: 10.1093/cvr/cvae038. Cardiovasc Res. 2024. PMID: 38400709 Free PMC article.
49 results