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CCR7 Sulfotyrosine Enhances CCL21 Binding.
Phillips AJ, Taleski D, Koplinski CA, Getschman AE, Moussouras NA, Richard AM, Peterson FC, Dwinell MB, Volkman BF, Payne RJ, Veldkamp CT. Phillips AJ, et al. Among authors: veldkamp ct. Int J Mol Sci. 2017 Aug 25;18(9):1857. doi: 10.3390/ijms18091857. Int J Mol Sci. 2017. PMID: 28841151 Free PMC article.
Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7.
Jørgensen AS, Larsen O, Uetz-von Allmen E, Lückmann M, Legler DF, Frimurer TM, Veldkamp CT, Hjortø GM, Rosenkilde MM. Jørgensen AS, et al. Among authors: veldkamp ct. Front Immunol. 2019 Sep 13;10:2156. doi: 10.3389/fimmu.2019.02156. eCollection 2019. Front Immunol. 2019. PMID: 31572374 Free PMC article.
The dimeric form of CXCL12 binds to atypical chemokine receptor 1.
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. Gutjahr JC, et al. Among authors: veldkamp ct. Sci Signal. 2021 Aug 17;14(696):eabc9012. doi: 10.1126/scisignal.abc9012. Sci Signal. 2021. PMID: 34404752 Free PMC article.
The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus.
Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM. Jørgensen AS, et al. Among authors: veldkamp ct. Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978. doi: 10.1007/s00018-021-03930-7. Epub 2021 Sep 29. Cell Mol Life Sci. 2021. PMID: 34586443 Free PMC article.
Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.
Veldkamp CT, Kiermaier E, Gabel-Eissens SJ, Gillitzer ML, Lippner DR, DiSilvio FA, Mueller CJ, Wantuch PL, Chaffee GR, Famiglietti MW, Zgoba DM, Bailey AA, Bah Y, Engebretson SJ, Graupner DR, Lackner ER, LaRosa VD, Medeiros T, Olson ML, Phillips AJ, Pyles H, Richard AM, Schoeller SJ, Touzeau B, Williams LG, Sixt M, Peterson FC. Veldkamp CT, et al. Biochemistry. 2015 Jul 14;54(27):4163-6. doi: 10.1021/acs.biochem.5b00560. Epub 2015 Jul 6. Biochemistry. 2015. PMID: 26115234 Free PMC article.
31 results