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An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis.
Pérez-Carreón JI, Martínez-Pérez L, Loredo ML, Yañez-Maldonado L, Velasco-Loyden G, Vidrio-Gómez S, Ramírez-Salcedo J, Hernández-Luis F, Velázquez-Martínez I, Suárez-Cuenca JA, Hernández-Muñoz R, de Sánchez VC. Pérez-Carreón JI, et al. Int J Biochem Cell Biol. 2010 Feb;42(2):287-96. doi: 10.1016/j.biocel.2009.11.005. Epub 2009 Nov 13. Int J Biochem Cell Biol. 2010. PMID: 19914391
Functional, Metabolic, and Dynamic Mitochondrial Changes in the Rat Cirrhosis-Hepatocellular Carcinoma Model and the Protective Effect of IFC-305.
Chávez E, Lozano-Rosas MG, Domínguez-López M, Velasco-Loyden G, Rodríguez-Aguilera JR, José-Nuñez C, Tuena de Gómez-Puyou M, Chagoya de Sánchez V. Chávez E, et al. Among authors: velasco loyden g. J Pharmacol Exp Ther. 2017 May;361(2):292-302. doi: 10.1124/jpet.116.239301. Epub 2017 Feb 16. J Pharmacol Exp Ther. 2017. PMID: 28209723
Diminished S-adenosylmethionine biosynthesis and its metabolism in a model of hepatocellular carcinoma is recuperated by an adenosine derivative.
Lozano-Rosas MG, Chávez E, Velasco-Loyden G, Domínguez-López M, Martínez-Pérez L, Chagoya De Sánchez V. Lozano-Rosas MG, et al. Among authors: velasco loyden g. Cancer Biol Ther. 2020;21(1):81-94. doi: 10.1080/15384047.2019.1665954. Epub 2019 Sep 25. Cancer Biol Ther. 2020. PMID: 31552788 Free PMC article.
An adenosine derivative prevents the alterations observed in metabolic syndrome in a rat model induced by a rich high-fat diet and sucrose supplementation.
Chávez E, Aparicio-Cadena AR, Velasco-Loyden G, Lozano-Rosas MG, Domínguez-López M, Cancino-Bello A, Torres N, Tovar AR, Cabrera-Aguilar A, Chagoya-de Sánchez V. Chávez E, et al. Among authors: velasco loyden g. PLoS One. 2023 Oct 5;18(10):e0292448. doi: 10.1371/journal.pone.0292448. eCollection 2023. PLoS One. 2023. PMID: 37796781 Free PMC article.
An adenosine derivative promotes mitochondrial supercomplexes reorganization and restoration of mitochondria structure and bioenergetics in a diethylnitrosamine-induced hepatocellular carcinoma model.
García-Carrillo R, Molina-Pelayo FA, Zarate-Lopez D, Cabrera-Aguilar A, Ortega-Domínguez B, Domínguez-López M, Chiquete-Félix N, Dagnino-Acosta A, Velasco-Loyden G, Chávez E, Castro-Sánchez L, de Sánchez VC. García-Carrillo R, et al. Among authors: velasco loyden g. Sci Rep. 2024 Mar 15;14(1):6348. doi: 10.1038/s41598-024-56306-9. Sci Rep. 2024. PMID: 38491051 Free PMC article.
Role of autophagy in the chemopreventive effect of the IFC-305 compound in the sequential model of cirrhosis-hepatocellular carcinoma in the rat and in vitro.
Chávez E, Velasco-Loyden G, Lozano-Rosas MG, Aguilar-Maldonado B, Muciño-Hernández G, Castro-Obregón S, Chagoya de Sánchez V. Chávez E, et al. Among authors: velasco loyden g. Am J Cancer Res. 2020 Jun 1;10(6):1844-1856. eCollection 2020. Am J Cancer Res. 2020. PMID: 32642295 Free PMC article.
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