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Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior.
Delbès AS, Quiñones M, Gobet C, Castel J, Denis RGP, Berthelet J, Weger BD, Challet E, Charpagne A, Metairon S, Piccand J, Kraus M, Rohde BH, Bial J, Wilson EM, Vedin LL, Minniti ME, Pedrelli M, Parini P, Gachon F, Luquet S. Delbès AS, et al. Among authors: vedin ll. Sci Adv. 2023 May 19;9(20):eadf2982. doi: 10.1126/sciadv.adf2982. Epub 2023 May 17. Sci Adv. 2023. PMID: 37196091 Free PMC article.
Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.
Minniti ME, Pedrelli M, Vedin LL, Delbès AS, Denis RGP, Öörni K, Sala C, Pirazzini C, Thiagarajan D, Nurmi HJ, Grompe M, Mills K, Garagnani P, Ellis ECS, Strom SC, Luquet SH, Wilson EM, Bial J, Steffensen KR, Parini P. Minniti ME, et al. Among authors: vedin ll. Hepatology. 2020 Aug;72(2):656-670. doi: 10.1002/hep.31052. Epub 2020 Mar 23. Hepatology. 2020. PMID: 31785104 Free PMC article.
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice.
Pramfalk C, Ahmed O, Pedrelli M, Minniti ME, Luquet S, Denis RG, Olin M, Härdfeldt J, Vedin LL, Steffensen KR, Rydén M, Hodson L, Eriksson M, Parini P. Pramfalk C, et al. Among authors: vedin ll. J Intern Med. 2022 Aug;292(2):296-307. doi: 10.1111/joim.13450. Epub 2022 Jan 13. J Intern Med. 2022. PMID: 34982494
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Liang N, et al. Among authors: vedin ll. Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z. Nat Commun. 2019. PMID: 30975991 Free PMC article.
Liver X receptors induce antiproliferative effects in basal-like breast cancer.
Haugen MH, von der Lippe Gythfeldt H, Egeland EV, Svartdal Normann L, Pandya AD, Vedin LL, Juell S, Tenstad E, Øy GF, Kristian A, Marangoni E, Sørlie T, Steffensen K, Maelandsmo GM, Engebraaten O. Haugen MH, et al. Among authors: vedin ll. Mol Oncol. 2023 Oct;17(10):2041-2055. doi: 10.1002/1878-0261.13476. Epub 2023 Jun 30. Mol Oncol. 2023. PMID: 37341140 Free PMC article.
15 results