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Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation.
Lopez-Pelaez M, Young L, Vazquez-Chantada M, Nelson N, Durant S, Wilkinson RW, Poon E, Gaspar M, Valge-Archer V, Smith P, Dovedi SJ. Lopez-Pelaez M, et al. Among authors: vazquez chantada m. Oncoimmunology. 2022 Sep 13;11(1):2117321. doi: 10.1080/2162402X.2022.2117321. eCollection 2022. Oncoimmunology. 2022. PMID: 36117525 Free PMC article.
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
Goldberg FW, Ting AKT, Beattie D, Lamont GM, Fallan C, Finlay MRV, Williamson B, Schimpl M, Harmer AR, Adeyemi OB, Nordell P, Cronin AS, Vazquez-Chantada M, Barratt D, Ramos-Montoya A, Cadogan EB, Davies BR. Goldberg FW, et al. Among authors: vazquez chantada m. ACS Med Chem Lett. 2022 Jul 7;13(8):1295-1301. doi: 10.1021/acsmedchemlett.2c00172. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978693 Free PMC article.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Fok JHL, Ramos-Montoya A, Vazquez-Chantada M, Wijnhoven PWG, Follia V, James N, Farrington PM, Karmokar A, Willis SE, Cairns J, Nikkilä J, Beattie D, Lamont GM, Finlay MRV, Wilson J, Smith A, O'Connor LO, Ling S, Fawell SE, O'Connor MJ, Hollingsworth SJ, Dean E, Goldberg FW, Davies BR, Cadogan EB. Fok JHL, et al. Among authors: vazquez chantada m. Nat Commun. 2019 Nov 7;10(1):5065. doi: 10.1038/s41467-019-12836-9. Nat Commun. 2019. PMID: 31699977 Free PMC article.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
Goldberg FW, Finlay MRV, Ting AKT, Beattie D, Lamont GM, Fallan C, Wrigley GL, Schimpl M, Howard MR, Williamson B, Vazquez-Chantada M, Barratt DG, Davies BR, Cadogan EB, Ramos-Montoya A, Dean E. Goldberg FW, et al. Among authors: vazquez chantada m. J Med Chem. 2020 Apr 9;63(7):3461-3471. doi: 10.1021/acs.jmedchem.9b01684. Epub 2020 Jan 15. J Med Chem. 2020. PMID: 31851518
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.
Cromm PM, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN. Cromm PM, et al. Among authors: vazquez chantada m. Chembiochem. 2019 Dec 13;20(24):2987-2990. doi: 10.1002/cbic.201900615. Epub 2019 Nov 19. Chembiochem. 2019. PMID: 31680402 Free PMC article.
Rfx2 is required for spermatogenesis in the mouse.
Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH. Shawlot W, et al. Genesis. 2015 Sep;53(9):604-611. doi: 10.1002/dvg.22880. Epub 2015 Aug 18. Genesis. 2015. PMID: 26248850 Free PMC article.
Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes.
Cano A, Vazquez-Chantada M, Conde-Vancells J, Gonzalez-Lahera A, Mosen-Ansorena D, Blanco FJ, Clément K, Aron-Wisnewsky J, Tran A, Gual P, García-Monzón C, Caballería J, Castro A, Martínez-Chantar ML, Mato JM, Zhu H, Finnell RH, Aransay AM. Cano A, et al. Among authors: vazquez chantada m. Biomedicines. 2023 Jan 31;11(2):337. doi: 10.3390/biomedicines11020337. Biomedicines. 2023. PMID: 36830876 Free PMC article.
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML. Vázquez-Chantada M, et al. Gastroenterology. 2010 May;138(5):1943-53. doi: 10.1053/j.gastro.2010.01.032. Epub 2010 Jan 25. Gastroenterology. 2010. PMID: 20102719 Free PMC article.
28 results