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Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2.
Tramonti A, Cuyàs E, Encinar JA, Pietzke M, Paone A, Verdura S, Arbusà A, Martin-Castillo B, Giardina G, Joven J, Vazquez A, Contestabile R, Cutruzzolà F, Menendez JA. Tramonti A, et al. Among authors: vazquez a. Cancers (Basel). 2021 Aug 9;13(16):4009. doi: 10.3390/cancers13164009. Cancers (Basel). 2021. PMID: 34439169 Free PMC article.
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vazquez A, Patel KJ. Burgos-Barragan G, et al. Among authors: vazquez a. Nature. 2017 Aug 31;548(7669):549-554. doi: 10.1038/nature23481. Epub 2017 Aug 16. Nature. 2017. PMID: 28813411 Free PMC article.
Increased formate overflow is a hallmark of oxidative cancer.
Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton JP, Dornier E, Sumpton D, Mackay GM, Blyth K, Patel KJ, Niclou SP, Vazquez A. Meiser J, et al. Among authors: vazquez a. Nat Commun. 2018 Apr 10;9(1):1368. doi: 10.1038/s41467-018-03777-w. Nat Commun. 2018. PMID: 29636461 Free PMC article.
Formate metabolism in health and disease.
Pietzke M, Meiser J, Vazquez A. Pietzke M, et al. Among authors: vazquez a. Mol Metab. 2020 Mar;33:23-37. doi: 10.1016/j.molmet.2019.05.012. Epub 2019 Jul 30. Mol Metab. 2020. PMID: 31402327 Free PMC article. Review.
Formate induces a metabolic switch in nucleotide and energy metabolism.
Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Oizel K, et al. Among authors: vazquez a. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. Cell Death Dis. 2020. PMID: 32366892 Free PMC article.
Impact of Formate Supplementation on Body Weight and Plasma Amino Acids.
Dhayade S, Pietzke M, Wiesheu R, Tait-Mulder J, Athineos D, Sumpton D, Coffelt S, Blyth K, Vazquez A. Dhayade S, et al. Among authors: vazquez a. Nutrients. 2020 Jul 22;12(8):2181. doi: 10.3390/nu12082181. Nutrients. 2020. PMID: 32708052 Free PMC article.
Amino acid dependent formaldehyde metabolism in mammals.
Pietzke M, Burgos-Barragan G, Wit N, Tait-Mulder J, Sumpton D, Mackay GM, Patel KJ, Vazquez A. Pietzke M, et al. Among authors: vazquez a. Commun Chem. 2020 Jun 16;3(1):78. doi: 10.1038/s42004-020-0324-z. Commun Chem. 2020. PMID: 36703413 Free PMC article.
1,387 results