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Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.
Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, Scarry SM, Aubé J, Yang G, Ouerfelli O, Schnappinger D, Ioerger TR, Engelhart CA, McConnell JA, McAulay K, Fay A, Roubert C, Sacchettini J, Nathan C. Ballinger E, et al. Among authors: vaubourgeix j. Science. 2019 Feb 1;363(6426):eaau8959. doi: 10.1126/science.aau8959. Science. 2019. PMID: 30705156 Free PMC article.
Targeting the Proteostasis Network for Mycobacterial Drug Discovery.
Lupoli TJ, Vaubourgeix J, Burns-Huang K, Gold B. Lupoli TJ, et al. Among authors: vaubourgeix j. ACS Infect Dis. 2018 Apr 13;4(4):478-498. doi: 10.1021/acsinfecdis.7b00231. Epub 2018 Mar 2. ACS Infect Dis. 2018. PMID: 29465983 Free PMC article. Review.
Multiform antimicrobial resistance from a metabolic mutation.
Schrader SM, Botella H, Jansen R, Ehrt S, Rhee K, Nathan C, Vaubourgeix J. Schrader SM, et al. Among authors: vaubourgeix j. Sci Adv. 2021 Aug 27;7(35):eabh2037. doi: 10.1126/sciadv.abh2037. Print 2021 Aug. Sci Adv. 2021. PMID: 34452915 Free PMC article.
Biology of antimicrobial resistance and approaches to combat it.
Schrader SM, Vaubourgeix J, Nathan C. Schrader SM, et al. Among authors: vaubourgeix j. Sci Transl Med. 2020 Jun 24;12(549):eaaz6992. doi: 10.1126/scitranslmed.aaz6992. Sci Transl Med. 2020. PMID: 32581135 Free PMC article. Review.
Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress.
Harnagel A, Lopez Quezada L, Park SW, Baranowski C, Kieser K, Jiang X, Roberts J, Vaubourgeix J, Yang A, Nelson B, Fay A, Rubin E, Ehrt S, Nathan C, Lupoli TJ. Harnagel A, et al. Among authors: vaubourgeix j. Mol Microbiol. 2021 Feb;115(2):272-289. doi: 10.1111/mmi.14615. Epub 2020 Nov 3. Mol Microbiol. 2021. PMID: 32996193 Free PMC article.
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.
Vaubourgeix J, Lin G, Dhar N, Chenouard N, Jiang X, Botella H, Lupoli T, Mariani O, Yang G, Ouerfelli O, Unser M, Schnappinger D, McKinney J, Nathan C. Vaubourgeix J, et al. Cell Host Microbe. 2015 Feb 11;17(2):178-90. doi: 10.1016/j.chom.2014.12.008. Epub 2015 Jan 22. Cell Host Microbe. 2015. PMID: 25620549 Free PMC article.
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