Varughese KI - Search Results

1

Drug resistance in Mycobacterium tuberculosis and targeting the l,d-transpeptidase enzyme.

Gokulan K, Varughese KI. Gokulan K, et al. Among authors: varughese ki. Drug Dev Res. 2019 Feb;80(1):11-18. doi: 10.1002/ddr.21455. Epub 2018 Oct 12. Drug Dev Res. 2019. PMID: 30312987 Review.

2

Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation.

Gokulan K, Khare S, Cerniglia CE, Foley SL, Varughese KI. Gokulan K, et al. Among authors: varughese ki. AAPS J. 2018 Mar 9;20(2):44. doi: 10.1208/s12248-018-0193-x. AAPS J. 2018. PMID: 29524047

3

Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites.

Peterson EC, Celikel R, Gokulan K, Varughese KI. Peterson EC, et al. Among authors: varughese ki. PLoS One. 2013 Dec 5;8(12):e82690. doi: 10.1371/journal.pone.0082690. eCollection 2013. PLoS One. 2013. PMID: 24349338 Free PMC article.

4

Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein.

Thakkar S, Wang X, Khaidakov M, Dai Y, Gokulan K, Mehta JL, Varughese KI. Thakkar S, et al. Among authors: varughese ki. Sci Rep. 2015 Nov 18;5:16740. doi: 10.1038/srep16740. Sci Rep. 2015. PMID: 26578342 Free PMC article.

5

Analysis of Protein-protein Interaction Interface between Yeast Mitochondrial Proteins Rim1 and Pif1 Using Chemical Cross-linking Mass Spectrometry.

Zybailov B, Gokulan K, Wiese J, Ramanagoudr-Bhojappa R, Byrd AK, Glazko G, Jaiswal M, Mackintosh S, Varughese KI, Raney KD. Zybailov B, et al. Among authors: varughese ki. J Proteomics Bioinform. 2015 Nov;8(11):243-252. doi: 10.4172/jpb.1000376. Epub 2015 Nov 19. J Proteomics Bioinform. 2015. PMID: 26807012 Free PMC article.

6

Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability.

Compadre CM, Singh A, Thakkar S, Zheng G, Breen PJ, Ghosh S, Kiaei M, Boerma M, Varughese KI, Hauer-Jensen M. Compadre CM, et al. Among authors: varughese ki. Drug Dev Res. 2014 Feb;75(1):10-22. doi: 10.1002/ddr.21162. Epub 2013 Dec 26. Drug Dev Res. 2014. PMID: 24648045 Free PMC article.

7

Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.

Celikel R, Peterson EC, Owens SM, Varughese KI. Celikel R, et al. Among authors: varughese ki. Protein Sci. 2009 Nov;18(11):2336-45. doi: 10.1002/pro.244. Protein Sci. 2009. PMID: 19760665 Free PMC article.

8

Amino acid identity at one position within the alpha1 helix of both the histidine kinase and the response regulator of the WalRK and PhoPR two-component systems plays a crucial role in the specificity of phosphotransfer.

Jende I, Varughese KI, Devine KM. Jende I, et al. Among authors: varughese ki. Microbiology (Reading). 2010 Jun;156(Pt 6):1848-1859. doi: 10.1099/mic.0.037515-0. Epub 2010 Feb 18. Microbiology (Reading). 2010. PMID: 20167622 Free article.

9

ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain.

Celikel R, Veldore VH, Mathews I, Devine KM, Varughese KI. Celikel R, et al. Among authors: varughese ki. Acta Crystallogr D Biol Crystallogr. 2012 Jul;68(Pt 7):839-45. doi: 10.1107/S090744491201373X. Epub 2012 Jun 15. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22751669 Free PMC article.

10

Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.

Thakkar S, Nanaware-Kharade N, Celikel R, Peterson EC, Varughese KI. Thakkar S, et al. Among authors: varughese ki. Sci Rep. 2014 Jan 14;4:3673. doi: 10.1038/srep03673. Sci Rep. 2014. PMID: 24419156 Free PMC article.

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