Vargiu AV - Search Results

1

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.

Plé C, Tam HK, Vieira Da Cruz A, Compagne N, Jiménez-Castellanos JC, Müller RT, Pradel E, Foong WE, Malloci G, Ballée A, Kirchner MA, Moshfegh P, Herledan A, Herrmann A, Deprez B, Willand N, Vargiu AV, Pos KM, Flipo M, Hartkoorn RC. Plé C, et al. Among authors: vargiu av. Nat Commun. 2022 Jan 10;13(1):115. doi: 10.1038/s41467-021-27726-2. Nat Commun. 2022. PMID: 35013254 Free PMC article.

2

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

Vargiu AV, Collu F, Schulz R, Pos KM, Zacharias M, Kleinekathöfer U, Ruggerone P. Vargiu AV, et al. J Am Chem Soc. 2011 Jul 20;133(28):10704-7. doi: 10.1021/ja202666x. Epub 2011 Jun 27. J Am Chem Soc. 2011. PMID: 21707050

3

RND efflux pumps: structural information translated into function and inhibition mechanisms.

Ruggerone P, Murakami S, Pos KM, Vargiu AV. Ruggerone P, et al. Among authors: vargiu av. Curr Top Med Chem. 2013;13(24):3079-100. doi: 10.2174/15680266113136660220. Curr Top Med Chem. 2013. PMID: 24200360 Review.

4

Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors.

Vargiu AV, Ruggerone P, Opperman TJ, Nguyen ST, Nikaido H. Vargiu AV, et al. Antimicrob Agents Chemother. 2014 Oct;58(10):6224-34. doi: 10.1128/AAC.03283-14. Epub 2014 Aug 11. Antimicrob Agents Chemother. 2014. PMID: 25114133 Free PMC article.

5

A Database of Force-Field Parameters, Dynamics, and Properties of Antimicrobial Compounds.

Malloci G, Vargiu AV, Serra G, Bosin A, Ruggerone P, Ceccarelli M. Malloci G, et al. Among authors: vargiu av. Molecules. 2015 Aug 3;20(8):13997-4021. doi: 10.3390/molecules200813997. Molecules. 2015. PMID: 26247924 Free PMC article.

6

Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pump.

Kinana AD, Vargiu AV, May T, Nikaido H. Kinana AD, et al. Among authors: vargiu av. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1405-10. doi: 10.1073/pnas.1525143113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787896 Free PMC article.

7

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.

Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ. Sjuts H, et al. Among authors: vargiu av. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3509-14. doi: 10.1073/pnas.1602472113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976576 Free PMC article.

8

Editorial: Bad Bugs in the XXIst Century: Resistance Mediated by Multi-Drug Efflux Pumps in Gram-Negative Bacteria.

Vargiu AV, Pos KM, Poole K, Nikaido H. Vargiu AV, et al. Front Microbiol. 2016 May 31;7:833. doi: 10.3389/fmicb.2016.00833. eCollection 2016. Front Microbiol. 2016. PMID: 27303401 Free PMC article. No abstract available.

9

Effect of site-directed mutations in multidrug efflux pump AcrB examined by quantitative efflux assays.

Kinana AD, Vargiu AV, Nikaido H. Kinana AD, et al. Among authors: vargiu av. Biochem Biophys Res Commun. 2016 Nov 25;480(4):552-557. doi: 10.1016/j.bbrc.2016.10.083. Epub 2016 Oct 24. Biochem Biophys Res Commun. 2016. PMID: 27789287 Free PMC article.

10

Computational modelling of efflux pumps and their inhibitors.

Ramaswamy VK, Cacciotto P, Malloci G, Vargiu AV, Ruggerone P. Ramaswamy VK, et al. Among authors: vargiu av. Essays Biochem. 2017 Mar 3;61(1):141-156. doi: 10.1042/EBC20160065. Print 2017 Feb 28. Essays Biochem. 2017. PMID: 28258237 Review.

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