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Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.
Jury N, Abarzua S, Diaz I, Guerra MV, Ampuero E, Cubillos P, Martinez P, Herrera-Soto A, Arredondo C, Rojas F, Manterola M, Rojas A, Montecino M, Varela-Nallar L, van Zundert B. Jury N, et al. Among authors: varela nallar l. Clin Epigenetics. 2020 Feb 18;12(1):32. doi: 10.1186/s13148-020-0816-9. Clin Epigenetics. 2020. PMID: 32070418 Free PMC article.
NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac.
Bustos FJ, Jury N, Martinez P, Ampuero E, Campos M, Abarzúa S, Jaramillo K, Ibing S, Mardones MD, Haensgen H, Kzhyshkowska J, Tevy MF, Neve R, Sanhueza M, Varela-Nallar L, Montecino M, van Zundert B. Bustos FJ, et al. J Cell Physiol. 2017 Dec;232(12):3677-3692. doi: 10.1002/jcp.25843. Epub 2017 May 11. J Cell Physiol. 2017. PMID: 28160495
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice.
Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B. Bustos FJ, et al. Brain. 2017 Dec 1;140(12):3252-3268. doi: 10.1093/brain/awx272. Brain. 2017. PMID: 29155979 Free PMC article.
Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution.
Calderón-Garcidueñas L, Herrera-Soto A, Jury N, Maher BA, González-Maciel A, Reynoso-Robles R, Ruiz-Rudolph P, van Zundert B, Varela-Nallar L. Calderón-Garcidueñas L, et al. Among authors: varela nallar l. Environ Res. 2020 Apr;183:109226. doi: 10.1016/j.envres.2020.109226. Epub 2020 Feb 4. Environ Res. 2020. PMID: 32045727
Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala.
Linsambarth S, Carvajal FJ, Moraga-Amaro R, Mendez L, Tamburini G, Jimenez I, Verdugo DA, Gómez GI, Jury N, Martínez P, van Zundert B, Varela-Nallar L, Retamal MA, Martin C, Altenberg GA, Fiori MC, Cerpa W, Orellana JA, Stehberg J. Linsambarth S, et al. Among authors: varela nallar l. FASEB J. 2022 Feb;36(2):e22134. doi: 10.1096/fj.202100798RR. FASEB J. 2022. PMID: 35061296
52 results