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A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira A, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino A, Breault DT, Agar NYR, Mostoslavsky R. Sebastian C, et al. Among authors: vara messler m. Nat Commun. 2022 Mar 21;13(1):1503. doi: 10.1038/s41467-022-29085-y. Nat Commun. 2022. PMID: 35314684 Free PMC article.
Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers.
Derouane F, Desgres M, Moroni C, Ambroise J, Berlière M, Van Bockstal MR, Galant C, van Marcke C, Vara-Messler M, Hutten SJ, Jonkers J, Mourao L, Scheele CLGJ, Duhoux FP, Corbet C. Derouane F, et al. Among authors: vara messler m. Breast Cancer Res. 2024 Feb 19;26(1):29. doi: 10.1186/s13058-024-01788-8. Breast Cancer Res. 2024. PMID: 38374113 Free PMC article.
Tumorigenic effect mediated by ROS/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma.
Garay MI, Comba A, Vara Messler M, Barotto NN, Silva RA, Repossi G, Quiroga PL, Mazzudulli GM, Brunotto MN, Pasqualini ME. Garay MI, et al. Among authors: vara messler m. Prostaglandins Other Lipid Mediat. 2021 Aug;155:106564. doi: 10.1016/j.prostaglandins.2021.106564. Epub 2021 May 15. Prostaglandins Other Lipid Mediat. 2021. PMID: 34004336
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid.
Comba A, Almada LL, Tolosa EJ, Iguchi E, Marks DL, Vara Messler M, Silva R, Fernandez-Barrena MG, Enriquez-Hesles E, Vrabel AL, Botta B, Di Marcotulio L, Ellenrieder V, Eynard AR, Pasqualini ME, Fernandez-Zapico ME. Comba A, et al. Among authors: vara messler m. J Biol Chem. 2016 Jan 22;291(4):1933-1947. doi: 10.1074/jbc.M115.691972. Epub 2015 Nov 24. J Biol Chem. 2016. PMID: 26601952 Free PMC article.
13 results