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Distinct roles of the C-terminal 11th transmembrane helix and luminal extension in the partial reactions determining the high Ca2+ affinity of sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2b (SERCA2b).
Clausen JD, Vandecaetsbeek I, Wuytack F, Vangheluwe P, Andersen JP. Clausen JD, et al. Among authors: vangheluwe p. J Biol Chem. 2012 Nov 16;287(47):39460-9. doi: 10.1074/jbc.M112.397331. Epub 2012 Sep 28. J Biol Chem. 2012. PMID: 23024360 Free PMC article.
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, Morimoto T, Hasegawa K, Sadoshima J, Vangheluwe P, Hajjar RJ, Park WJ, Kho C. Gorski PA, et al. Among authors: vangheluwe p. Circ Res. 2019 Apr 26;124(9):e63-e80. doi: 10.1161/CIRCRESAHA.118.313865. Circ Res. 2019. PMID: 30786847 Free PMC article.
Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases.
Vandecaetsbeek I, Christensen SB, Liu H, Van Veldhoven PP, Waelkens E, Eggermont J, Raeymaekers L, Møller JV, Nissen P, Wuytack F, Vangheluwe P. Vandecaetsbeek I, et al. Among authors: vangheluwe p. Biochim Biophys Acta. 2011 May;1813(5):1118-27. doi: 10.1016/j.bbamcr.2010.12.020. Epub 2011 Jan 4. Biochim Biophys Acta. 2011. PMID: 21215281 Free article.
A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Holemans T, Sørensen DM, van Veen S, Martin S, Hermans D, Kemmer GC, Van den Haute C, Baekelandt V, Günther Pomorski T, Agostinis P, Wuytack F, Palmgren M, Eggermont J, Vangheluwe P. Holemans T, et al. Among authors: vangheluwe p. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9040-5. doi: 10.1073/pnas.1508220112. Epub 2015 Jul 1. Proc Natl Acad Sci U S A. 2015. PMID: 26134396 Free PMC article.
Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).
Chen J, De Raeymaecker J, Hovgaard JB, Smaardijk S, Vandecaetsbeek I, Wuytack F, Møller JV, Eggermont J, De Maeyer M, Christensen SB, Vangheluwe P. Chen J, et al. Among authors: vangheluwe p. J Biol Chem. 2017 Apr 28;292(17):6938-6951. doi: 10.1074/jbc.M117.778431. Epub 2017 Mar 6. J Biol Chem. 2017. PMID: 28264934 Free PMC article.
Parkinson disease related ATP13A2 evolved early in animal evolution.
Sørensen DM, Holemans T, van Veen S, Martin S, Arslan T, Haagendahl IW, Holen HW, Hamouda NN, Eggermont J, Palmgren M, Vangheluwe P. Sørensen DM, et al. Among authors: vangheluwe p. PLoS One. 2018 Mar 5;13(3):e0193228. doi: 10.1371/journal.pone.0193228. eCollection 2018. PLoS One. 2018. PMID: 29505581 Free PMC article.
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