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Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound.
Kieffer C, Primas N, Hutter S, Merckx A, Reininger L, Bach S, Ruchaud S, Gaillard F, Laget M, Amrane D, Hervé L, Castera-Ducros C, Renault J, Dumètre A, Rault S, Doerig C, Rathelot P, Vanelle P, Azas N, Verhaeghe P. Kieffer C, et al. Among authors: vanelle p. Bioorg Med Chem. 2024 Mar 15;102:117654. doi: 10.1016/j.bmc.2024.117654. Epub 2024 Feb 28. Bioorg Med Chem. 2024. PMID: 38452406
Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability.
Lagardère P, Mustière R, Amanzougaghene N, Hutter S, Casanova M, Franetich JF, Tajeri S, Malzert-Fréon A, Corvaisier S, Since M, Azas N, Vanelle P, Verhaeghe P, Primas N, Mazier D, Masurier N, Lisowski V. Lagardère P, et al. Among authors: vanelle p. Eur J Med Chem. 2023 Dec 5;261:115873. doi: 10.1016/j.ejmech.2023.115873. Epub 2023 Oct 13. Eur J Med Chem. 2023. PMID: 37857143
New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability.
Lagardère P, Mustière R, Amanzougaghene N, Hutter S, Casanova M, Franetich JF, Tajeri S, Malzert-Fréon A, Corvaisier S, Azas N, Vanelle P, Verhaeghe P, Primas N, Mazier D, Masurier N, Lisowski V. Lagardère P, et al. Among authors: vanelle p. Eur J Med Chem. 2023 Mar 5;249:115115. doi: 10.1016/j.ejmech.2023.115115. Epub 2023 Jan 13. Eur J Med Chem. 2023. PMID: 36680984
172 results