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The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity.
Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R. Bricambert J, et al. Among authors: vander wal mn. Nat Commun. 2018 May 29;9(1):2092. doi: 10.1038/s41467-018-04361-y. Nat Commun. 2018. PMID: 29844386 Free PMC article.
A reactivity-based probe of the intracellular labile ferrous iron pool.
Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. Spangler B, et al. Among authors: vander wal mn. Nat Chem Biol. 2016 Sep;12(9):680-5. doi: 10.1038/nchembio.2116. Epub 2016 Jul 4. Nat Chem Biol. 2016. PMID: 27376690 Free PMC article.
In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.
Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. Aron AT, et al. Among authors: vander wal mn. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12669-12674. doi: 10.1073/pnas.1708747114. Epub 2017 Nov 14. Proc Natl Acad Sci U S A. 2017. PMID: 29138321 Free PMC article.
Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.
Chuang C, Collibee S, Ashcraft L, Wang W, Vander Wal M, Wang X, Hwee DT, Wu Y, Wang J, Chin ER, Cremin P, Zamora J, Hartman J, Schaletzky J, Wehri E, Robertson LA, Malik FI, Morgan BP. Chuang C, et al. J Med Chem. 2021 Oct 14;64(19):14142-14152. doi: 10.1021/acs.jmedchem.1c01290. Epub 2021 Oct 4. J Med Chem. 2021. PMID: 34606259 Free article.