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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA. Palsson-McDermott EM, et al. Among authors: vander heiden m. Cell Metab. 2015 Jan 6;21(1):65-80. doi: 10.1016/j.cmet.2014.12.005. Cell Metab. 2015. PMID: 25565206 Free PMC article.
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Jiang JK, et al. Among authors: vander heiden mg. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3387-93. doi: 10.1016/j.bmcl.2010.04.015. Epub 2010 Apr 11. Bioorg Med Chem Lett. 2010. PMID: 20451379 Free PMC article.
Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD. Düvel K, et al. Among authors: vander heiden mg. Mol Cell. 2010 Jul 30;39(2):171-83. doi: 10.1016/j.molcel.2010.06.022. Mol Cell. 2010. PMID: 20670887 Free PMC article.
ATP consumption promotes cancer metabolism.
Israelsen WJ, Vander Heiden MG. Israelsen WJ, et al. Cell. 2010 Nov 24;143(5):669-71. doi: 10.1016/j.cell.2010.11.010. Cell. 2010. PMID: 21111226 Free article.
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas CJ, Boxer MB. Walsh MJ, et al. Among authors: vander heiden mg. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6322-7. doi: 10.1016/j.bmcl.2011.08.114. Epub 2011 Sep 14. Bioorg Med Chem Lett. 2011. PMID: 21958545 Free PMC article.
Metabolic pathway alterations that support cell proliferation.
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Vander Heiden MG, et al. Cold Spring Harb Symp Quant Biol. 2011;76:325-34. doi: 10.1101/sqb.2012.76.010900. Epub 2012 Jan 19. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22262476 Review.
METabolic adaptations in the tumor MYCroenvironment.
Davidson SM, Vander Heiden MG. Davidson SM, et al. Among authors: vander heiden mg. Cell Metab. 2012 Feb 8;15(2):131-3. doi: 10.1016/j.cmet.2012.01.005. Cell Metab. 2012. PMID: 22326214 Free article.
241 results