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Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Evers-van Gogh IJ, Van den Bossche J, Speijer D, Kim Y, Wessels L, Zelcer N, Zwart W, Kalkhoven E, de Vries CJ. Koenis DS, et al. Among authors: van weeghel m, van den bossche j, van loenen pb. Cell Rep. 2018 Aug 21;24(8):2127-2140.e7. doi: 10.1016/j.celrep.2018.07.065. Cell Rep. 2018. PMID: 30134173 Free PMC article.
Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP. Van den Bossche J, et al. Among authors: van der velden s, van den berg sm. Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008. Cell Rep. 2016. PMID: 27732846 Free article.
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.
Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J. Baardman J, et al. Among authors: van weeghel m, van den bossche j, van der velden s. Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092. Cell Rep. 2018. PMID: 30463003 Free article.
Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages.
Harber KJ, de Goede KE, Verberk SGS, Meinster E, de Vries HE, van Weeghel M, de Winther MPJ, Van den Bossche J. Harber KJ, et al. Among authors: van weeghel m, van den bossche j. Metabolites. 2020 Sep 15;10(9):372. doi: 10.3390/metabo10090372. Metabolites. 2020. PMID: 32942769 Free PMC article.
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.
Baardman J, Verberk SGS, van der Velden S, Gijbels MJJ, van Roomen CPPA, Sluimer JC, Broos JY, Griffith GR, Prange KHM, van Weeghel M, Lakbir S, Molenaar D, Meinster E, Neele AE, Kooij G, de Vries HE, Lutgens E, Wellen KE, de Winther MPJ, Van den Bossche J. Baardman J, et al. Among authors: van weeghel m, van den bossche j, van der velden s, van roomen cppa. Nat Commun. 2020 Dec 8;11(1):6296. doi: 10.1038/s41467-020-20141-z. Nat Commun. 2020. PMID: 33293558 Free PMC article.
Keep your macrophages fit for healthy aging.
Van den Bossche J, Leenen PJM. Van den Bossche J, et al. Cell Metab. 2021 Mar 2;33(3):468-470. doi: 10.1016/j.cmet.2021.02.004. Cell Metab. 2021. PMID: 33657391 Free article.
Macrophages are metabolically heterogeneous within the tumor microenvironment.
Geeraerts X, Fernández-Garcia J, Hartmann FJ, de Goede KE, Martens L, Elkrim Y, Debraekeleer A, Stijlemans B, Vandekeere A, Rinaldi G, De Rycke R, Planque M, Broekaert D, Meinster E, Clappaert E, Bardet P, Murgaski A, Gysemans C, Nana FA, Saeys Y, Bendall SC, Laoui D, Van den Bossche J, Fendt SM, Van Ginderachter JA. Geeraerts X, et al. Among authors: van den bossche j, van ginderachter ja. Cell Rep. 2021 Dec 28;37(13):110171. doi: 10.1016/j.celrep.2021.110171. Cell Rep. 2021. PMID: 34965415 Free article.
An integrated toolbox to profile macrophage immunometabolism.
Verberk SGS, de Goede KE, Gorki FS, van Dierendonck XAMH, Argüello RJ, Van den Bossche J. Verberk SGS, et al. Among authors: van den bossche j, van dierendonck xamh. Cell Rep Methods. 2022 Mar 28;2(4):100192. doi: 10.1016/j.crmeth.2022.100192. eCollection 2022 Apr 25. Cell Rep Methods. 2022. PMID: 35497494 Free PMC article.
d-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation.
de Goede KE, Harber KJ, Gorki FS, Verberk SGS, Groh LA, Keuning ED, Struys EA, van Weeghel M, Haschemi A, de Winther MPJ, van Dierendonck XAMH, Van den Bossche J. de Goede KE, et al. Among authors: van weeghel m, van den bossche j, van dierendonck xamh. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166427. doi: 10.1016/j.bbadis.2022.166427. Epub 2022 May 6. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35526742 Free article.
143 results