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Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1.
Puimège L, Van Hauwermeiren F, Steeland S, Van Ryckeghem S, Vandewalle J, Lodens S, Dejager L, Vandevyver S, Staelens J, Timmermans S, Vandenbroucke RE, Libert C. Puimège L, et al. Among authors: van ryckeghem s. EMBO Mol Med. 2015 Aug;7(8):1004-17. doi: 10.15252/emmm.201405010. EMBO Mol Med. 2015. PMID: 25995337 Free PMC article.
TNFR1 inhibition with a Nanobody protects against EAE development in mice.
Steeland S, Van Ryckeghem S, Van Imschoot G, De Rycke R, Toussaint W, Vanhoutte L, Vanhove C, De Vos F, Vandenbroucke RE, Libert C. Steeland S, et al. Among authors: van ryckeghem s. Sci Rep. 2017 Oct 20;7(1):13646. doi: 10.1038/s41598-017-13984-y. Sci Rep. 2017. PMID: 29057962 Free PMC article.
Efficient analysis of mouse genome sequences reveal many nonsense variants.
Steeland S, Timmermans S, Van Ryckeghem S, Hulpiau P, Saeys Y, Van Montagu M, Vandenbroucke RE, Libert C. Steeland S, et al. Among authors: van ryckeghem s. Proc Natl Acad Sci U S A. 2016 May 17;113(20):5670-5. doi: 10.1073/pnas.1605076113. Epub 2016 May 4. Proc Natl Acad Sci U S A. 2016. PMID: 27147605 Free PMC article.
Topical imiquimod yields systemic effects due to unintended oral uptake.
Grine L, Steeland S, Van Ryckeghem S, Ballegeer M, Lienenklaus S, Weiss S, Sanders NN, Vandenbroucke RE, Libert C. Grine L, et al. Among authors: van ryckeghem s. Sci Rep. 2016 Jan 28;6:20134. doi: 10.1038/srep20134. Sci Rep. 2016. PMID: 26818707 Free PMC article.