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Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.
Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ. Bobkov V, et al. Among authors: van der woning b, van loy t, van der vliet hj, van hout a. Biochem Pharmacol. 2018 Dec;158:413-424. doi: 10.1016/j.bcp.2018.10.014. Epub 2018 Oct 17. Biochem Pharmacol. 2018. PMID: 30342023 Free article.
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.
Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D. Van Hout A, et al. Among authors: van der woning b, van loy t. Biochem Pharmacol. 2018 Dec;158:402-412. doi: 10.1016/j.bcp.2018.10.015. Epub 2018 Oct 17. Biochem Pharmacol. 2018. PMID: 30342024
Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.
Cain AN , Carder Freeman TN , Roewe KD , Cockriel DL , Hasley TR , Maples RD , Allbritton EMA , D'Huys T , van Loy T , Burke BP , Prior TJ , Schols D , Archibald SJ , Hubin TJ . Cain AN , et al. Among authors: van loy t. Dalton Trans. 2019 Feb 19;48(8):2785-2801. doi: 10.1039/c8dt04728f. Dalton Trans. 2019. PMID: 30729243 Free PMC article.
54 results