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A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.
Beckers J, Tharkeshwar AK, Fumagalli L, Contardo M, Van Schoor E, Fazal R, Thal DR, Chandran S, Mancuso R, Van Den Bosch L, Van Damme P. Beckers J, et al. Among authors: van schoor e, van damme p, van den bosch l. Acta Neuropathol Commun. 2023 Sep 18;11(1):151. doi: 10.1186/s40478-023-01648-0. Acta Neuropathol Commun. 2023. PMID: 37723585 Free PMC article.
An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition.
Van den Bosch L, Van Damme P, Vleminckx V, Van Houtte E, Lemmens G, Missiaen L, Callewaert G, Robberecht W. Van den Bosch L, et al. Among authors: van damme p, van houtte e. Neuropharmacology. 2002 Apr;42(5):706-13. doi: 10.1016/s0028-3908(02)00010-2. Neuropharmacology. 2002. PMID: 11985829
Upregulation of HSP27 in a transgenic model of ALS.
Vleminckx V, Van Damme P, Goffin K, Delye H, Van Den Bosch L, Robberecht W. Vleminckx V, et al. Among authors: van damme p, van den bosch l. J Neuropathol Exp Neurol. 2002 Nov;61(11):968-74. doi: 10.1093/jnen/61.11.968. J Neuropathol Exp Neurol. 2002. PMID: 12430713
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.
Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, Van Damme P, Rutten B, Man WY, De Mol M, Wyns S, Manka D, Vermeulen K, Van Den Bosch L, Mertens N, Schmitz C, Robberecht W, Conway EM, Collen D, Moons L, Carmeliet P. Storkebaum E, et al. Among authors: van damme p, van den bosch l. Nat Neurosci. 2005 Jan;8(1):85-92. doi: 10.1038/nn1360. Epub 2004 Nov 28. Nat Neurosci. 2005. PMID: 15568021 Free article.
315 results