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Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Torazza C, Provenzano F, Gallia E, Cerminara M, Balbi M, Bonifacino T, Tessitore S, Ravera S, Usai C, Musante I, Puliti A, Van Den Bosch L, Jafar-Nejad P, Rigo F, Milanese M, Bonanno G. Torazza C, et al. Among authors: van den bosch l. Cells. 2023 Jul 27;12(15):1952. doi: 10.3390/cells12151952. Cells. 2023. PMID: 37566031 Free PMC article.
Upregulation of HSP27 in a transgenic model of ALS.
Vleminckx V, Van Damme P, Goffin K, Delye H, Van Den Bosch L, Robberecht W. Vleminckx V, et al. Among authors: van damme p, van den bosch l. J Neuropathol Exp Neurol. 2002 Nov;61(11):968-74. doi: 10.1093/jnen/61.11.968. J Neuropathol Exp Neurol. 2002. PMID: 12430713
Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse.
Taes I, Goris A, Lemmens R, van Es MA, van den Berg LH, Chio A, Traynor BJ, Birve A, Andersen P, Slowik A, Tomik B, Brown RH Jr, Shaw CE, Al-Chalabi A, Boonen S, Van Den Bosch L, Dubois B, Van Damme P, Robberecht W. Taes I, et al. Among authors: van es ma, van den berg lh, van damme p, van den bosch l. Neurology. 2010 May 25;74(21):1687-93. doi: 10.1212/WNL.0b013e3181e042f7. Neurology. 2010. PMID: 20498436 Free PMC article.
Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice.
Staats KA, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, Parys JB, Hisatsune C, Mikoshiba K, Van Damme P, Robberecht W, Van Den Bosch L. Staats KA, et al. Among authors: van damme p, van den bosch l. Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):210-3. doi: 10.1016/j.bbrc.2012.10.094. Epub 2012 Nov 3. Biochem Biophys Res Commun. 2012. PMID: 23131553
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.
Taes I, Timmers M, Hersmus N, Bento-Abreu A, Van Den Bosch L, Van Damme P, Auwerx J, Robberecht W. Taes I, et al. Among authors: van damme p, van den bosch l. Hum Mol Genet. 2013 May 1;22(9):1783-90. doi: 10.1093/hmg/ddt028. Epub 2013 Jan 30. Hum Mol Genet. 2013. PMID: 23364049 Free article.
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis.
Philips T, Bento-Abreu A, Nonneman A, Haeck W, Staats K, Geelen V, Hersmus N, Küsters B, Van Den Bosch L, Van Damme P, Richardson WD, Robberecht W. Philips T, et al. Among authors: van damme p, van den bosch l. Brain. 2013 Feb;136(Pt 2):471-82. doi: 10.1093/brain/aws339. Epub 2013 Jan 31. Brain. 2013. PMID: 23378219 Free PMC article.
Energy metabolism in ALS: an underappreciated opportunity?
Vandoorne T, De Bock K, Van Den Bosch L. Vandoorne T, et al. Among authors: van den bosch l. Acta Neuropathol. 2018 Apr;135(4):489-509. doi: 10.1007/s00401-018-1835-x. Epub 2018 Mar 16. Acta Neuropathol. 2018. PMID: 29549424 Free PMC article. Review.
In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.
Bonifacino T, Provenzano F, Gallia E, Ravera S, Torazza C, Bossi S, Ferrando S, Puliti A, Van Den Bosch L, Bonanno G, Milanese M. Bonifacino T, et al. Among authors: van den bosch l. Neurobiol Dis. 2019 Sep;129:79-92. doi: 10.1016/j.nbd.2019.05.007. Epub 2019 May 15. Neurobiol Dis. 2019. PMID: 31102766
Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations.
Bursch F, Kalmbach N, Naujock M, Staege S, Eggenschwiler R, Abo-Rady M, Japtok J, Guo W, Hensel N, Reinhardt P, Boeckers TM, Cantz T, Sterneckert J, Van Den Bosch L, Hermann A, Petri S, Wegner F. Bursch F, et al. Among authors: van den bosch l. Hum Mol Genet. 2019 Sep 1;28(17):2835-2850. doi: 10.1093/hmg/ddz107. Hum Mol Genet. 2019. PMID: 31108504
312 results