Valko K - Search Results

1

Modeling cellular pharmacokinetics of 14- and 15-membered macrolides with physicochemical properties.

Stepanić V, Koštrun S, Malnar I, Hlevnjak M, Butković K, Ćaleta I, Dukši M, Kragol G, Makaruha-Stegić O, Mikac L, Ralić J, Tatić I, Tavčar B, Valko K, Zulfikari S, Munić V. Stepanić V, et al. Among authors: valko k. J Med Chem. 2011 Feb 10;54(3):719-33. doi: 10.1021/jm101317f. Epub 2011 Jan 5. J Med Chem. 2011. PMID: 21207938

2

Physicochemical profile of macrolides and their comparison with small molecules.

Stepanić V, Ziher D, Gabelica-Marković V, Jelić D, Nunhuck S, Valko K, Koštrun S. Stepanić V, et al. Among authors: valko k. Eur J Med Chem. 2012 Jan;47(1):462-72. doi: 10.1016/j.ejmech.2011.11.016. Epub 2011 Nov 17. Eur J Med Chem. 2012. PMID: 22152985

3

Estimation of volume of distribution in humans from high throughput HPLC-based measurements of human serum albumin binding and immobilized artificial membrane partitioning.

Hollósy F, Valkó K, Hersey A, Nunhuck S, Kéri G, Bevan C. Hollósy F, et al. Among authors: valko k. J Med Chem. 2006 Nov 30;49(24):6958-71. doi: 10.1021/jm050957i. J Med Chem. 2006. PMID: 17125249

4

Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties.

Thansandote P, Harris RM, Dexter HL, Simpson GL, Pal S, Upton RJ, Valko K. Thansandote P, et al. Among authors: valko k. Bioorg Med Chem. 2015 Jan 15;23(2):322-7. doi: 10.1016/j.bmc.2014.11.034. Epub 2014 Nov 28. Bioorg Med Chem. 2015. PMID: 25533323

5

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.

Bertrand SM, Ancellin N, Beaufils B, Bingham RP, Borthwick JA, Boullay AB, Boursier E, Carter PS, Chung CW, Churcher I, Dodic N, Fouchet MH, Fournier C, Francis PL, Gummer LA, Herry K, Hobbs A, Hobbs CI, Homes P, Jamieson C, Nicodeme E, Pickett SD, Reid IH, Simpson GL, Sloan LA, Smith SE, Somers DO, Spitzfaden C, Suckling CJ, Valko K, Washio Y, Young RJ. Bertrand SM, et al. Among authors: valko k. J Med Chem. 2015 Sep 24;58(18):7140-63. doi: 10.1021/acs.jmedchem.5b00313. Epub 2015 Jul 2. J Med Chem. 2015. PMID: 26090771

6

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

Tedesco R, Chai D, Darcy MG, Dhanak D, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Sarisky RT, Shaw AN, Valko KL, Wiggall KJ, Zimmerman MN, Duffy KJ. Tedesco R, et al. Among authors: valko kl. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4354-8. doi: 10.1016/j.bmcl.2009.05.080. Epub 2009 May 27. Bioorg Med Chem Lett. 2009. PMID: 19505821

7

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

Borthwick AD, Davies DE, Exall AM, Hatley RJ, Hughes JA, Irving WR, Livermore DG, Sollis SL, Nerozzi F, Valko KL, Allen MJ, Perren M, Shabbir SS, Woollard PM, Price MA. Borthwick AD, et al. J Med Chem. 2006 Jul 13;49(14):4159-70. doi: 10.1021/jm060073e. J Med Chem. 2006. PMID: 16821776

8

Synthesis and characterization of amino acid substituted sunitinib analogues for the treatment of AML.

Nemes Z, Takács-Novák K, Völgyi G, Valko K, Béni S, Horváth Z, Szokol B, Breza N, Dobos J, Szántai-Kis C, Illyés E, Boros S, Kok RJ, Őrfi L. Nemes Z, et al. Among authors: valko k. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2391-2398. doi: 10.1016/j.bmcl.2018.06.026. Epub 2018 Jun 18. Bioorg Med Chem Lett. 2018. PMID: 29935772

9

Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)).

Valko K, My Du C, Bevan C, Reynolds DP, Abraham MH. Valko K, et al. Curr Med Chem. 2001 Jul;8(9):1137-46. doi: 10.2174/0929867013372643. Curr Med Chem. 2001. PMID: 11472245 Review.

10

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.

Georgakopoulos N, Talapatra S, Dikovskaya D, Dayalan Naidu S, Higgins M, Gatliff J, Ayhan A, Nikoloudaki R, Schaap M, Valko K, Javid F, Dinkova-Kostova AT, Kozielski F, Wells G. Georgakopoulos N, et al. Among authors: valko k. J Med Chem. 2022 May 26;65(10):7380-7398. doi: 10.1021/acs.jmedchem.2c00457. Epub 2022 May 12. J Med Chem. 2022. PMID: 35549469 Free PMC article.

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