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TUSC3: functional duality of a cancer gene.
Vašíčková K, Horak P, Vaňhara P. Vašíčková K, et al. Among authors: vanhara p. Cell Mol Life Sci. 2018 Mar;75(5):849-857. doi: 10.1007/s00018-017-2660-4. Epub 2017 Sep 19. Cell Mol Life Sci. 2018. PMID: 28929175 Review.
hVps37A Status affects prognosis and cetuximab sensitivity in ovarian cancer.
Wittinger M, Vanhara P, El-Gazzar A, Savarese-Brenner B, Pils D, Anees M, Grunt TW, Sibilia M, Holcmann M, Horvat R, Schemper M, Zeillinger R, Schöfer C, Dolznig H, Horak P, Krainer M. Wittinger M, et al. Among authors: vanhara p. Clin Cancer Res. 2011 Dec 15;17(24):7816-27. doi: 10.1158/1078-0432.CCR-11-0408. Epub 2011 Oct 20. Clin Cancer Res. 2011. PMID: 22016507
Methylation status of TUSC3 is a prognostic factor in ovarian cancer.
Pils D, Horak P, Vanhara P, Anees M, Petz M, Alfanz A, Gugerell A, Wittinger M, Gleiss A, Auner V, Tong D, Zeillinger R, Braicu EI, Sehouli J, Krainer M. Pils D, et al. Among authors: vanhara p. Cancer. 2013 Mar 1;119(5):946-54. doi: 10.1002/cncr.27850. Epub 2012 Oct 23. Cancer. 2013. PMID: 23096450 Free article.
Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to-mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells.
Kratochvílová K, Horak P, Ešner M, Souček K, Pils D, Anees M, Tomasich E, Dráfi F, Jurtíková V, Hampl A, Krainer M, Vaňhara P. Kratochvílová K, et al. Among authors: vanhara p. Int J Cancer. 2015 Sep 15;137(6):1330-40. doi: 10.1002/ijc.29502. Epub 2015 Mar 21. Int J Cancer. 2015. PMID: 25735931 Free article.
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation.
Samadder P, Suchánková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollár P, Fedr R, Ešner M, Jaroš J, Hampl A, Krejčí L, Paruch K, Souček K. Samadder P, et al. Among authors: vanhara p. Mol Cancer Ther. 2017 Sep;16(9):1831-1842. doi: 10.1158/1535-7163.MCT-17-0018. Epub 2017 Jun 15. Mol Cancer Ther. 2017. PMID: 28619751
A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis.
Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P, Kraus M, Bader J, Ferreira RB, Castellano RK, Law BK, Driessen C. Besse L, et al. Among authors: vanhara p. Haematologica. 2019 Sep;104(9):e415-e419. doi: 10.3324/haematol.2018.207704. Epub 2019 Feb 21. Haematologica. 2019. PMID: 30792209 Free PMC article. No abstract available.
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