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Page 1
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.
Torres S, Ortiz C, Bachtler N, Gu W, Grünewald LD, Kraus N, Schierwagen R, Hieber C, Meier C, Tyc O, Joseph Brol M, Uschner FE, Nijmeijer B, Welsch C, Berres ML, Garcia-Ruiz C, Fernandez-Checa JC, Trautwein C, Vogl TJ, Zeuzem S, Trebicka J, Klein S. Torres S, et al. Among authors: uschner fe. Hepatology. 2023 Apr 1;77(4):1228-1240. doi: 10.1002/hep.32746. Epub 2022 Oct 13. Hepatology. 2023. PMID: 35993369 Free PMC article.
Interleukin-22 in acute-on-chronic liver failure: A matter of ineffective levels, receptor dysregulation or defective signalling?
Schwarzkopf KM, Eberle L, Uschner FE, Klein S, Schierwagen R, Mücke MM, Schaefer L, Clària J, Zeuzem S, Hintermann E, Christen U, Lange CM, Trebicka J, Welsch C. Schwarzkopf KM, et al. Among authors: uschner fe. J Hepatol. 2020 Oct;73(4):980-982. doi: 10.1016/j.jhep.2020.05.012. Epub 2020 Jul 19. J Hepatol. 2020. PMID: 32698966 Free article. No abstract available.
β-Arrestin2 is increased in liver fibrosis in humans and rodents.
Schierwagen R, Dietrich P, Klein S, Uschner FE, Ortiz C, Tyc O, Torres S, Hellerbrand C, Sauerbruch T, Trebicka J. Schierwagen R, et al. Among authors: uschner fe. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27082-27084. doi: 10.1073/pnas.2014337117. Proc Natl Acad Sci U S A. 2020. PMID: 33144522 Free PMC article. No abstract available.
Rationale for the use of statins in liver disease.
Schierwagen R, Uschner FE, Magdaleno F, Klein S, Trebicka J. Schierwagen R, et al. Among authors: uschner fe. Am J Physiol Gastrointest Liver Physiol. 2017 May 1;312(5):G407-G412. doi: 10.1152/ajpgi.00441.2016. Epub 2017 Mar 9. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 28280144 Free article. Review.
TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor.
Klein S, Kleine CE, Pieper A, Granzow M, Gautsch S, Himmit M, Kahrmann K, Schierwagen R, Uschner FE, Magdaleno F, Naoum ME, Kristiansen G, Walther T, Bader M, Sauerbruch T, Trebicka J. Klein S, et al. Among authors: uschner fe. Sci Rep. 2019 Aug 12;9(1):11598. doi: 10.1038/s41598-019-48024-4. Sci Rep. 2019. PMID: 31406138 Free PMC article.
Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats.
Cremonese C, Schierwagen R, Uschner FE, Torres S, Tyc O, Ortiz C, Schulz M, Queck A, Kristiansen G, Bader M, Sauerbruch T, Weiskirchen R, Walther T, Trebicka J, Klein S. Cremonese C, et al. Among authors: uschner fe. Int J Mol Sci. 2020 May 7;21(9):3308. doi: 10.3390/ijms21093308. Int J Mol Sci. 2020. PMID: 32392802 Free PMC article.
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.
Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Janicko M, Steib C, Reiberger T, Acevedo J, Gatti P, Bernal W, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Bendtsen F, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solè C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Özdogan OC, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Curto A, Pitarch C, Putignano A, Moreno E, Shawcross D, Aguilar F, Clària J, Ponzo P, Jansen C, Vitalis Z, Zaccherini G, Balogh B, Vargas V, Montagnese S, Alessandria C, Bernardi M, Ginès P, Jalan R, Moreau R, Angeli P, Arroyo V; PREDICT STUDY group of the EASL-CLIF Consortium. Trebicka J, et al. Among authors: uschner fe. J Hepatol. 2020 Oct;73(4):842-854. doi: 10.1016/j.jhep.2020.06.013. Epub 2020 Jul 13. J Hepatol. 2020. PMID: 32673741 Free article.
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.
Trebicka J, Fernandez J, Papp M, Caraceni P, Laleman W, Gambino C, Giovo I, Uschner FE, Jansen C, Jimenez C, Mookerjee R, Gustot T, Albillos A, Bañares R, Jarcuska P, Steib C, Reiberger T, Acevedo J, Gatti P, Shawcross DL, Zeuzem S, Zipprich A, Piano S, Berg T, Bruns T, Danielsen KV, Coenraad M, Merli M, Stauber R, Zoller H, Ramos JP, Solé C, Soriano G, de Gottardi A, Gronbaek H, Saliba F, Trautwein C, Kani HT, Francque S, Ryder S, Nahon P, Romero-Gomez M, Van Vlierberghe H, Francoz C, Manns M, Garcia-Lopez E, Tufoni M, Amoros A, Pavesi M, Sanchez C, Praktiknjo M, Curto A, Pitarch C, Putignano A, Moreno E, Bernal W, Aguilar F, Clària J, Ponzo P, Vitalis Z, Zaccherini G, Balogh B, Gerbes A, Vargas V, Alessandria C, Bernardi M, Ginès P, Moreau R, Angeli P, Jalan R, Arroyo V; PREDICT STUDY group of the EASL-CLIF CONSORTIUM. Trebicka J, et al. Among authors: uschner fe. J Hepatol. 2021 May;74(5):1097-1108. doi: 10.1016/j.jhep.2020.11.019. Epub 2020 Nov 20. J Hepatol. 2021. PMID: 33227350 Free article.
Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease.
Tyc O, Jansen C, Schierwagen R, Uschner FE, Israelsen M, Klein S, Ortiz C, Strassburg CP, Zeuzem S, Gu W, Torres S, Praktiknjo M, Kersting S, Langheinrich M, Nattermann J, Servant F, Arumugam M, Krag A, Lelouvier B, Weismüller TJ, Trebicka J. Tyc O, et al. Among authors: uschner fe. Liver Transpl. 2020 Dec;26(12):1652-1657. doi: 10.1002/lt.25882. Epub 2020 Oct 7. Liver Transpl. 2020. PMID: 32885580 Free PMC article. No abstract available.
75 results