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Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation.
Pearlstein RA, MacCannell KA, Erdemli G, Yeola S, Helmlinger G, Hu QY, Farid R, Egan W, Whitebread S, Springer C, Beck J, Wang HR, Maciejewski M, Urban L, Duca JS. Pearlstein RA, et al. Among authors: urban l. Curr Top Med Chem. 2016;16(16):1792-818. doi: 10.2174/1568026616666160315142156. Curr Top Med Chem. 2016. PMID: 26975508 Review.
Mapping adverse drug reactions in chemical space.
Scheiber J, Jenkins JL, Sukuru SC, Bender A, Mikhailov D, Milik M, Azzaoui K, Whitebread S, Hamon J, Urban L, Glick M, Davies JW. Scheiber J, et al. Among authors: urban l. J Med Chem. 2009 May 14;52(9):3103-7. doi: 10.1021/jm801546k. J Med Chem. 2009. PMID: 19378990
In vitro safety pharmacology profiling: what else beyond hERG?
Hamon J, Whitebread S, Techer-Etienne V, Le Coq H, Azzaoui K, Urban L. Hamon J, et al. Among authors: urban l. Future Med Chem. 2009 Jul;1(4):645-65. doi: 10.4155/fmc.09.51. Future Med Chem. 2009. PMID: 21426031 Review.
417 results