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Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.
Tarantini S, Yabluchanskiy A, Csipo T, Fulop G, Kiss T, Balasubramanian P, DelFavero J, Ahire C, Ungvari A, Nyúl-Tóth Á, Farkas E, Benyo Z, Tóth A, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: ungvari a, ungvari z. Geroscience. 2019 Oct;41(5):533-542. doi: 10.1007/s11357-019-00101-2. Epub 2019 Nov 2. Geroscience. 2019. PMID: 31679124 Free PMC article.
IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.
Tarantini S, Balasubramanian P, Yabluchanskiy A, Ashpole NM, Logan S, Kiss T, Ungvari A, Nyúl-Tóth Á, Schwartzman ML, Benyo Z, Sonntag WE, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: ungvari a, ungvari z. Geroscience. 2021 Apr;43(2):901-911. doi: 10.1007/s11357-021-00350-0. Epub 2021 Mar 6. Geroscience. 2021. PMID: 33674953 Free PMC article.
Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype.
Tarantini S, Nyúl-Tóth Á, Yabluchanskiy A, Csipo T, Mukli P, Balasubramanian P, Ungvari A, Toth P, Benyo Z, Sonntag WE, Ungvari Z, Csiszar A. Tarantini S, et al. Among authors: ungvari a, ungvari z. Geroscience. 2021 Oct;43(5):2387-2394. doi: 10.1007/s11357-021-00405-2. Epub 2021 Aug 12. Geroscience. 2021. PMID: 34383203 Free PMC article.
Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice.
Tarantini S, Balasubramanian P, Delfavero J, Csipo T, Yabluchanskiy A, Kiss T, Nyúl-Tóth Á, Mukli P, Toth P, Ahire C, Ungvari A, Benyo Z, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: ungvari a, ungvari z. Geroscience. 2021 Oct;43(5):2427-2440. doi: 10.1007/s11357-021-00440-z. Epub 2021 Aug 24. Geroscience. 2021. PMID: 34427858 Free PMC article.
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice.
Nyul-Toth A, Fulop GA, Tarantini S, Kiss T, Ahire C, Faakye JA, Ungvari A, Toth P, Toth A, Csiszar A, Ungvari Z. Nyul-Toth A, et al. Among authors: ungvari a, ungvari z. Geroscience. 2022 Apr;44(2):805-816. doi: 10.1007/s11357-021-00504-0. Epub 2022 Jan 6. Geroscience. 2022. PMID: 34989944 Free PMC article.
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
Kiss T, Nyúl-Tóth Á, DelFavero J, Balasubramanian P, Tarantini S, Faakye J, Gulej R, Ahire C, Ungvari A, Yabluchanskiy A, Wiley G, Garman L, Ungvari Z, Csiszar A. Kiss T, et al. Among authors: ungvari a, ungvari z. Geroscience. 2022 Apr;44(2):661-681. doi: 10.1007/s11357-022-00521-7. Epub 2022 Jan 31. Geroscience. 2022. PMID: 35098444 Free PMC article.
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
Kiss T, Nyúl-Tóth Á, Gulej R, Tarantini S, Csipo T, Mukli P, Ungvari A, Balasubramanian P, Yabluchanskiy A, Benyo Z, Conley SM, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z. Kiss T, et al. Among authors: ungvari a. Geroscience. 2022 Apr;44(2):953-981. doi: 10.1007/s11357-022-00519-1. Epub 2022 Feb 5. Geroscience. 2022. PMID: 35124764 Free PMC article.
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