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Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F. Sanches M, et al. Among authors: uehling d. Nat Commun. 2014 Aug 28;5:4202. doi: 10.1038/ncomms5202. Nat Commun. 2014. PMID: 25164867 Free PMC article.
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.
Mahoney DJ, Lefebvre C, Allan K, Brun J, Sanaei CA, Baird S, Pearce N, Grönberg S, Wilson B, Prakesh M, Aman A, Isaac M, Mamai A, Uehling D, Al-Awar R, Falls T, Alain T, Stojdl DF. Mahoney DJ, et al. Among authors: uehling d. Cancer Cell. 2011 Oct 18;20(4):443-56. doi: 10.1016/j.ccr.2011.09.005. Cancer Cell. 2011. PMID: 22014571 Free article.
Use of kinase inhibitors to correct ΔF508-CFTR function.
Trzcinska-Daneluti AM, Nguyen L, Jiang C, Fladd C, Uehling D, Prakesch M, Al-awar R, Rotin D. Trzcinska-Daneluti AM, et al. Among authors: uehling d. Mol Cell Proteomics. 2012 Sep;11(9):745-57. doi: 10.1074/mcp.M111.016626. Epub 2012 Jun 14. Mol Cell Proteomics. 2012. PMID: 22700489 Free PMC article.
shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.
Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. Deng T, et al. Among authors: uehling d. Cancer Res. 2014 Apr 1;74(7):2119-30. doi: 10.1158/0008-5472.CAN-13-2138. Epub 2014 Jan 31. Cancer Res. 2014. PMID: 24487029
Small molecules reveal an alternative mechanism of Bax activation.
Brahmbhatt H, Uehling D, Al-Awar R, Leber B, Andrews D. Brahmbhatt H, et al. Among authors: uehling d. Biochem J. 2016 Apr 15;473(8):1073-83. doi: 10.1042/BCJ20160118. Epub 2016 Feb 25. Biochem J. 2016. PMID: 26916338 Free PMC article.
Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.
Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR. Grinshtein N, et al. Among authors: uehling d. Oncotarget. 2016 Sep 13;7(37):59360-59376. doi: 10.18632/oncotarget.10661. Oncotarget. 2016. PMID: 27449082 Free PMC article.
203 results