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A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Mol Cell. 2021 Sep 16;81(18):3848-3865.e19. doi: 10.1016/j.molcel.2021.08.028.
Mol Cell. 2021.
PMID: 34547241
Free article.
Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia.
Uchenunu O, Pollak M, Topisirovic I, Hulea L.
Uchenunu O, et al.
J Mol Endocrinol. 2019 Feb 1;62(2):R83-R103. doi: 10.1530/JME-18-0058.
J Mol Endocrinol. 2019.
PMID: 30072418
Free PMC article.
Review.
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Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin.
Papadopoli D, Uchenunu O, Palia R, Chekkal N, Hulea L, Topisirovic I, Pollak M, St-Pierre J.
Papadopoli D, et al. Among authors: uchenunu o.
Neoplasia. 2021 Apr;23(4):391-399. doi: 10.1016/j.neo.2021.02.003. Epub 2021 Mar 27.
Neoplasia. 2021.
PMID: 33784591
Free PMC article.
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Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells.
Uchenunu O, Zhdanov AV, Hutton P, Jovanovic P, Wang Y, Andreev DE, Hulea L, Papadopoli DJ, Avizonis D, Baranov PV, Pollak MN, Papkovsky DB, Topisirovic I.
Uchenunu O, et al.
FEBS Open Bio. 2022 May;12(5):959-982. doi: 10.1002/2211-5463.13398. Epub 2022 Apr 1.
FEBS Open Bio. 2022.
PMID: 35302710
Free PMC article.
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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I.
Hulea L, et al. Among authors: uchenunu o.
Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20.
Cell Metab. 2018.
PMID: 30244971
Free PMC article.
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PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis.
Mzoughi S, Fong JY, Papadopoli D, Koh CM, Hulea L, Pigini P, Di Tullio F, Andreacchio G, Hoppe MM, Wollmann H, Low D, Caldez MJ, Peng Y, Torre D, Zhao JN, Uchenunu O, Varano G, Motofeanu CM, Lakshmanan M, Teo SX, Wun CM, Perini G, Tan SY, Ong CB, Al-Haddawi M, Rajarethinam R, Hue SS, Lim ST, Ong CK, Huang D, Ng SB, Bernstein E, Hasson D, Wee KB, Kaldis P, Jeyasekharan A, Dominguez-Sola D, Topisirovic I, Guccione E.
Mzoughi S, et al. Among authors: uchenunu o.
Nat Commun. 2020 Jul 14;11(1):3520. doi: 10.1038/s41467-020-17064-0.
Nat Commun. 2020.
PMID: 32665551
Free PMC article.
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AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment.
Lo L, Uchenunu O, Botelho RJ, Antonescu CN, Karshafian R.
Lo L, et al. Among authors: uchenunu o.
iScience. 2022 Dec 28;26(2):105883. doi: 10.1016/j.isci.2022.105883. eCollection 2023 Feb 17.
iScience. 2022.
PMID: 36685038
Free PMC article.
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