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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R. Xu Y, et al. Nat Genet. 2022 Nov;54(11):1690-1701. doi: 10.1038/s41588-022-01202-z. Epub 2022 Oct 27. Nat Genet. 2022. PMID: 36303074 Free PMC article.
Physiology assays in human kidney organoids.
Freedman BS. Freedman BS. Am J Physiol Renal Physiol. 2022 Jun 1;322(6):F625-F638. doi: 10.1152/ajprenal.00400.2021. Epub 2022 Apr 4. Am J Physiol Renal Physiol. 2022. PMID: 35379001 Free PMC article. Review.
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations.
Helms L, Marchiano S, Stanaway IB, Hsiang TY, Juliar BA, Saini S, Zhao YT, Khanna A, Menon R, Alakwaa F, Mikacenic C, Morrell ED, Wurfel MM, Kretzler M, Harder JL, Murry CE, Himmelfarb J, Ruohola-Baker H, Bhatraju PK, Gale M Jr, Freedman BS. Helms L, et al. JCI Insight. 2021 Dec 22;6(24):e154882. doi: 10.1172/jci.insight.154882. JCI Insight. 2021. PMID: 34767537 Free PMC article.
Spatial transcriptional mapping of the human nephrogenic program.
Lindström NO, Sealfon R, Chen X, Parvez RK, Ransick A, De Sena Brandine G, Guo J, Hill B, Tran T, Kim AD, Zhou J, Tadych A, Watters A, Wong A, Lovero E, Grubbs BH, Thornton ME, McMahon JA, Smith AD, Ruffins SW, Armit C, Troyanskaya OG, McMahon AP. Lindström NO, et al. Dev Cell. 2021 Aug 23;56(16):2381-2398.e6. doi: 10.1016/j.devcel.2021.07.017. Dev Cell. 2021. PMID: 34428401 Free PMC article.
35 results