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Page 1
A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells.
Du L, Deiter F, Bouzidi MS, Billaud JN, Simmons G, Dabral P, Selvarajah S, Lingappa AF, Michon M, Yu SF, Paulvannan K, Manicassamy B, Lingappa VR, Boushey H, Greenland JR, Pillai SK. Du L, et al. Commun Biol. 2024 Apr 22;7(1):486. doi: 10.1038/s42003-024-06130-8. Commun Biol. 2024. PMID: 38649430 Free PMC article.
Proof-of-concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid.
Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS. Papini C, et al. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2320713121. doi: 10.1073/pnas.2320713121. Epub 2024 Apr 15. Proc Natl Acad Sci U S A. 2024. PMID: 38621119 Free PMC article.
SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility.
Kim SM, Kim EH, Casel MAB, Kim YI, Sun R, Kwak MJ, Yoo JS, Yu M, Yu KM, Jang SG, Rollon R, Choi JH, Gil J, Eun K, Kim H, Ensser A, Hwang J, Song MS, Kim MH, Jung JU, Choi YK. Kim SM, et al. Cell Rep. 2023 Sep 26;42(9):113077. doi: 10.1016/j.celrep.2023.113077. Epub 2023 Sep 6. Cell Rep. 2023. PMID: 37676771 Free article.
Identification of In Vitro Inhibitors of Monkeypox Replication.
Chiem K, Nogales A, Lorenzo M, Morales Vasquez D, Xiang Y, Gupta YK, Blasco R, de la Torre JC, Martínez-Sobrido L. Chiem K, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0474522. doi: 10.1128/spectrum.04745-22. Epub 2023 Jun 6. Microbiol Spectr. 2023. PMID: 37278625 Free PMC article.
Protocol for production and purification of SARS-CoV-2 3CLpro.
Mazzei L, Greene-Cramer R, Bafna K, Jovanovic A, De Falco A, Acton TB, Royer CA, Ciurli S, Montelione GT. Mazzei L, et al. STAR Protoc. 2023 May 5;4(2):102326. doi: 10.1016/j.xpro.2023.102326. Online ahead of print. STAR Protoc. 2023. PMID: 37235475 Free PMC article.