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Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ. Aguado J, et al. Among authors: tyshkovskiy a. Nat Aging. 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Nat Aging. 2023. PMID: 37957361 Free PMC article.
Chemically induced reprogramming to reverse cellular aging.
Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA. Yang JH, et al. Among authors: tyshkovskiy a. Aging (Albany NY). 2023 Jul 12;15(13):5966-5989. doi: 10.18632/aging.204896. Epub 2023 Jul 12. Aging (Albany NY). 2023. PMID: 37437248 Free PMC article.
Multi-omic rejuvenation and life span extension on exposure to youthful circulation.
Zhang B, Lee DE, Trapp A, Tyshkovskiy A, Lu AT, Bareja A, Kerepesi C, McKay LK, Shindyapina AV, Dmitriev SE, Baht GS, Horvath S, Gladyshev VN, White JP. Zhang B, et al. Among authors: tyshkovskiy a. Nat Aging. 2023 Aug;3(8):948-964. doi: 10.1038/s43587-023-00451-9. Epub 2023 Jul 27. Nat Aging. 2023. PMID: 37500973 Free PMC article.
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan.
Ribeiro R, Macedo JC, Costa M, Ustiyan V, Shindyapina AV, Tyshkovskiy A, Gomes RN, Castro JP, Kalin TV, Vasques-Nóvoa F, Nascimento DS, Dmitriev SE, Gladyshev VN, Kalinichenko VV, Logarinho E. Ribeiro R, et al. Among authors: tyshkovskiy a. Nat Aging. 2022 May;2(5):397-411. doi: 10.1038/s43587-022-00209-9. Epub 2022 May 5. Nat Aging. 2022. PMID: 37118067
A whole lifespan mouse multi-tissue DNA methylation clock.
Meer MV, Podolskiy DI, Tyshkovskiy A, Gladyshev VN. Meer MV, et al. Among authors: tyshkovskiy a. Elife. 2018 Nov 14;7:e40675. doi: 10.7554/eLife.40675. Elife. 2018. PMID: 30427307 Free PMC article.
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.
Zhang Z, Tian X, Lu JY, Boit K, Ablaeva J, Zakusilo FT, Emmrich S, Firsanov D, Rydkina E, Biashad SA, Lu Q, Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A, Gorbunova V. Zhang Z, et al. Among authors: tyshkovskiy a. Nature. 2023 Sep;621(7977):196-205. doi: 10.1038/s41586-023-06463-0. Epub 2023 Aug 23. Nature. 2023. PMID: 37612507 Free PMC article.
Molecular signatures of aneuploidy-driven adaptive evolution.
Kaya A, Mariotti M, Tyshkovskiy A, Zhou X, Hulke ML, Ma S, Gerashchenko MV, Koren A, Gladyshev VN. Kaya A, et al. Among authors: tyshkovskiy a. Nat Commun. 2020 Jan 30;11(1):588. doi: 10.1038/s41467-019-13669-2. Nat Commun. 2020. PMID: 32001709 Free PMC article.
32 results