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The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.
Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: tu y. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2313825120. doi: 10.1073/pnas.2313825120. Epub 2023 Oct 23. Proc Natl Acad Sci U S A. 2023. PMID: 37871217 Free PMC article.
Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures.
Song W, Yang Y, Heizer P, Tu Y, Weston TA, Kim JR, Munguia P, Jung H, Fong JL, Tran C, Ploug M, Beigneux AP, Young SG, Fong LG. Song W, et al. Among authors: tu y. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2219833120. doi: 10.1073/pnas.2219833120. Epub 2023 Feb 14. Proc Natl Acad Sci U S A. 2023. PMID: 36787365 Free PMC article.
GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.
Davies BS, Beigneux AP, Barnes RH 2nd, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. Davies BS, et al. Among authors: tu y. Cell Metab. 2010 Jul 7;12(1):42-52. doi: 10.1016/j.cmet.2010.04.016. Cell Metab. 2010. PMID: 20620994 Free PMC article.
Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.
Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH 2nd, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. Weinstein MM, et al. Among authors: tu y. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):230-5. doi: 10.1161/ATVBAHA.111.241406. Epub 2011 Dec 15. Arterioscler Thromb Vasc Biol. 2012. PMID: 22173228 Free PMC article.
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.
Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. Hu X, et al. Among authors: tu y. J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15. J Lipid Res. 2017. PMID: 27875259 Free PMC article.
NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.
He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. He C, et al. Among authors: tu y. Biochem Biophys Res Commun. 2018 Oct 12;504(4):899-902. doi: 10.1016/j.bbrc.2018.09.051. Epub 2018 Sep 15. Biochem Biophys Res Commun. 2018. PMID: 30224066 Free PMC article.
5,468 results