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Page 1
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology.
Boga SB, Alhassan AB, Cooper AB, Doll R, Shih NY, Shipps G, Deng Y, Zhu H, Nan Y, Sun R, Zhu L, Desai J, Patel M, Muppalla K, Gao X, Wang J, Yao X, Kelly J, Gudipati S, Paliwal S, Tsui HC, Wang T, Sherborne B, Xiao L, Hruza A, Buevich A, Zhang LK, Hesk D, Samatar AA, Carr D, Long B, Black S, Dayananth P, Windsor W, Kirschmeier P, Bishop R. Boga SB, et al. Among authors: tsui hc. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2029-2034. doi: 10.1016/j.bmcl.2018.04.063. Epub 2018 Apr 26. Bioorg Med Chem Lett. 2018. PMID: 29748051
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
Boga SB, Deng Y, Zhu L, Nan Y, Cooper AB, Shipps GW Jr, Doll R, Shih NY, Zhu H, Sun R, Wang T, Paliwal S, Tsui HC, Gao X, Yao X, Desai J, Wang J, Alhassan AB, Kelly J, Patel M, Muppalla K, Gudipati S, Zhang LK, Buevich A, Hesk D, Carr D, Dayananth P, Black S, Mei H, Cox K, Sherborne B, Hruza AW, Xiao L, Jin W, Long B, Liu G, Taylor SA, Kirschmeier P, Windsor WT, Bishop R, Samatar AA. Boga SB, et al. Among authors: tsui hc. ACS Med Chem Lett. 2018 Jun 14;9(7):761-767. doi: 10.1021/acsmedchemlett.8b00220. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034615 Free PMC article.
Cyclobutane derivatives as potent NK1 selective antagonists.
Wrobleski ML, Reichard GA, Paliwal S, Shah S, Tsui HC, Duffy RA, Lachowicz JE, Morgan CA, Varty GB, Shih NY. Wrobleski ML, et al. Among authors: tsui hc. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3859-63. doi: 10.1016/j.bmcl.2006.04.031. Epub 2006 May 8. Bioorg Med Chem Lett. 2006. PMID: 16682196
Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Hanisak J, Seganish WM, McElroy WT, Tang H, Zhang R, Tsui HC, Fischmann T, Tulshian D, Tata J, Sondey C, Devito K, Fossetta J, Garlisi CG, Lundell D, Niu X. Hanisak J, et al. Among authors: tsui hc. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4250-5. doi: 10.1016/j.bmcl.2016.07.048. Epub 2016 Jul 22. Bioorg Med Chem Lett. 2016. PMID: 27476420
Alternate routes to mnm5s2U synthesis in Gram-positive bacteria.
Jaroch M, Sun G, Tsui H-CT, Reed C, Sun J, Jörg M, Winkler ME, Rice KC, Dziergowska A, Stich TA, Dedon PC, Dos Santos PC, de Crécy-Lagard V. Jaroch M, et al. J Bacteriol. 2024 Apr 18;206(4):e0045223. doi: 10.1128/jb.00452-23. Epub 2024 Mar 29. J Bacteriol. 2024. PMID: 38551342 Free PMC article.
Alternate routes to mnm 5 s 2 U synthesis in Gram-positive bacteria.
Jaroch M, Sun G, Tsui HT, Reed C, Sun J, Jörg M, Winkler ME, Rice KC, Stich TA, Dedon PC, Dos Santos PC, de Crécy-Lagard V. Jaroch M, et al. bioRxiv [Preprint]. 2023 Dec 27:2023.12.21.572861. doi: 10.1101/2023.12.21.572861. bioRxiv. 2023. PMID: 38187551 Free PMC article. Updated. Preprint.
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