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In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera FJ, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH. Roper J, et al. Among authors: tsichlis pn. Nat Biotechnol. 2017 Jun;35(6):569-576. doi: 10.1038/nbt.3836. Epub 2017 May 1. Nat Biotechnol. 2017. PMID: 28459449 Free PMC article.
Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH. Roper J, et al. Among authors: tsichlis pn. Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211a. Nat Biotechnol. 2017. PMID: 29220013
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. Roper J, et al. Among authors: tsichlis pn. Cancer Lett. 2014 Jun 1;347(2):204-11. doi: 10.1016/j.canlet.2014.02.018. Epub 2014 Feb 24. Cancer Lett. 2014. PMID: 24576621 Free PMC article.
The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.
Serebrennikova OB, Paraskevopoulou MD, Aguado-Fraile E, Taraslia V, Ren W, Thapa G, Roper J, Du K, Croce CM, Tsichlis PN. Serebrennikova OB, et al. Among authors: tsichlis pn. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14039-14048. doi: 10.1073/pnas.1901465116. Epub 2019 Jun 25. Proc Natl Acad Sci U S A. 2019. PMID: 31239343 Free PMC article.
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.
Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. Serebrennikova OB, et al. Among authors: tsichlis pn. Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1082-91. doi: 10.1073/pnas.1115098109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451924 Free PMC article.
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing.
Laliotis GI, Chavdoula E, Paraskevopoulou MD, Kaba A, La Ferlita A, Singh S, Anastas V, Nair KA 2nd, Orlacchio A, Taraslia V, Vlachos I, Capece M, Hatzigeorgiou A, Palmieri D, Tsatsanis C, Alaimo S, Sehgal L, Carbone DP, Coppola V, Tsichlis PN. Laliotis GI, et al. Among authors: tsichlis pn. Nat Commun. 2021 Jul 30;12(1):4624. doi: 10.1038/s41467-021-24795-1. Nat Commun. 2021. PMID: 34330897 Free PMC article. Retracted.
219 results